Analysis of CD4 T cells from castrated animals. Testosterone levels had been observed to be inversely correlated to the strength of the immune response. Results provide insight into the molecular basis of this observation.
Kissick HT, Sanda MG, Dunn LK, Pellegrini KL et al. Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation. Proc Natl Acad Sci U S A 2014 Jul 8;111(27):9887-92. PMID: 24958858