Platelet-derived growth factor C transgenic model of hepatocellular carcinoma: liver stromal cells
Summary:
Analysis of liver stroma from 8.8-week-old PDGF-C transgenics wherein PDGF-C is ectopically expressed in hepatocytes. The transgenics develop progressive liver fibrosis with a high incidence of HCC. Results provide insight into PDGF-C-driven molecular changes in liver stroma contributing to HCC.
Wright JH, Johnson MM, Shimizu-Albergine M, Bauer RL et al. Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma. Int J Cancer 2014 Feb 15;134(4):778-88. PMID: 23929039
Lee JI, Wright JH, Johnson MM, Bauer RL et al. Role of Smad3 in platelet-derived growth factor-C-induced liver fibrosis. Am J Physiol Cell Physiol 2016 Mar 15;310(6):C436-45. PMID: 26632601
