Imatinib mesylate effect on patient peripheral T-cell lymphomas, not otherwise specified (PTCL/NOS) cells
Summary:
Analysis of patient PTCL/NOS cells treated with imatinib mesylate (1uM, 6h). PTCL/NOS tumors are characterized by aberrant expression of platelet-derived growth factor receptor α (PDGFRA). Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Piccaluga PP, Rossi M, Agostinelli C, Ricci F et al. Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway. Leukemia 2014 Aug;28(8):1687-97. PMID: 24480986
