Imatinib mesylate effect on EOL-1 eosinophilic leukemia cell line
Summary:
Analysis of EOL-1 cells treated with imatinib mesylate (1uM, 6h). EOL-1 cells carry the platelet derived growth factor receptor α (PDGFRA)/FIP1L1 fusion and exhibit constitutive PDGFRA activation. Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Piccaluga PP, Rossi M, Agostinelli C, Ricci F et al. Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway. Leukemia 2014 Aug;28(8):1687-97. PMID: 24480986
