CD40 activation effect on DBC1-deficient splenic B cells
Summary:
Analysis of DBC1-knockout splenic B cells following anti-CD40 activation. The deleted in breast cancer 1 (DBC1) gene was initially identified as part of the 8p22 chromosome region that is deleted in breast cancer. Results provide insight into the role of DBC1 in B cell function.
Kong S, Thiruppathi M, Qiu Q, Lin Z et al. DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity. J Immunol 2014 Dec 1;193(11):5515-24. PMID: 25362179
