Rho kinase inhibition effect on epidermal keratinocyte in vitro
Summary:
Analysis of primary epidermal keratinocytes treated with the Rho kinase inihibitor Y-27632. The lifespan of keratinocytes is extended indefinitely by culture in the presence of Y-27632. Results provide insight into the molecular basis of this lifespan extension.
Chapman S, McDermott DH, Shen K, Jang MK et al. The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional. Stem Cell Res Ther 2014 Apr 28;5(2):60. PMID: 24774536
