Survival motor neuron deficiency effect on somatodendritic compartment of cultured motoneurons
Summary:
Analysis of the somatodendritic compartment of cultured motoneurons depleted for survival motor neuron (Smn). Smn is the protein deficient in spinal muscular atrophy (SMA). Results provide insight into the somatodendritic mRNA content of degenerating motoneurons in vitro.
Saal L, Briese M, Kneitz S, Glinka M et al. Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation. RNA 2014 Nov;20(11):1789-802. PMID: 25246652
