NFATc1 deficiency effect on osteoclast differentiation in vitro
Summary:
Analysis of osteoclasts lacking the transcription factor NFATc1. Osteoclasts cultured in the presence of M-CSF and RANKL to induce differentiation. Results identify gene targets of NFATc1 in osteoclastogenesis.
Aliprantis AO, Ueki Y, Sulyanto R, Park A et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 2008 Nov;118(11):3775-89. PMID: 18846253
