DataSet Record GDS5620: Expression Profiles Data Analysis Tools Sample Subsets
Title: H3K79 histone methyl transferase DOT1L inhibitor Compound 55 effect on breast cancer cells: dose response
Cluster AnalysisGDS5620 Cluster Image
Summary: Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.
Organism: Homo sapiens
Platform: GPL10558: Illumina HumanHT-12 V4.0 expression beadchip
  • Zhang L, Deng L, Chen F, Yao Y et al. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget 2014 Nov 15;5(21):10665-77. PMID: 25359765
Reference Series: GSE56630 Sample count: 8
Value type: transformed count Series published: 2015/02/18