Retinoblastoma ∆G/∆G mutant allele effect on quiescent embryonic fibroblasts
Summary:
Analysis of retinoblastoma (RB) ∆G/∆G mutant MEFs deprived of serum to induce quiescence. The mutant allele disrupts RB protein (pRB) interactions with the transactivation domain of E2F transcription factors. Results provide insight into pRB functions in cell cycle control independent of E2F.
Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI et al. A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol 2014 Jun;34(11):2029-45. PMID: 24662053
