Protein tyrosine phosphatase receptor-δ and cyclin-dependent kinase inhibitor 2A deficiency effect on RCAS PDGFB/Nestin tv-A glioma model
Summary:
Analysis of RCAS PDGFB/Nestin tv-A glioma cells from Ptprd knockout and Cdkn2a/p16Ink4a knockout mice. PTPRD is a tumor suppressor of glioma that is often co-deleted with tumor suppressor p16INK4A. Results provide insight into the cooperative effects of PTPRD and p16INK4A loss in gliomagenesis.
Ortiz B, Fabius AW, Wu WH, Pedraza A et al. Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc Natl Acad Sci U S A 2014 Jun 3;111(22):8149-54. PMID: 24843164
