DataSet Record GDS5676: Expression Profiles Data Analysis Tools Sample Subsets
Title: Mutant isocitrate dehydrogenase 1 and 2 effect on hepatoblasts grown on collagen-coated plates
Cluster AnalysisGDS5676 Cluster Image
Summary: Analysis of hepatoblasts expressing mutant IDH1 (R132C) and mutant IDH2 (R172K) grown on collagen-coated plates. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into molecular pathways by which IDH mutations lead to tumor formation.
Organism: Mus musculus
Platform: GPL8321: [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
  • Saha SK, Parachoniak CA, Ghanta KS, Fitamant J et al. Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. Nature 2014 Sep 4;513(7516):110-4. PMID: 25043045
Reference Series: GSE57002 Sample count: 10
Value type: count Series published: 2014/04/30