DataSet Record GDS5816: Expression Profiles Data Analysis Tools Sample Subsets
Title: Methyltransferase EZH2 inhibition effect on ARID1A mutated ovarian clear cell cancer cell line
Cluster AnalysisGDS5816 Cluster Image
Summary: Analysis of ARID1A-mutated OVISE ovarian clear cell carcinoma (OCCC) cells restored with wild-type ARID1A or treated with GSK126, an inhibitor of epigenetic regulator EZH2. Epigenetic modifier ARID1A is often mutated in OCCC. Results provide insight into the role of epigenetic mechanisms in OCCC.
Organism: Homo sapiens
Platform: GPL10558: Illumina HumanHT-12 V4.0 expression beadchip
  • Bitler BG, Aird KM, Garipov A, Li H et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med 2015 Mar;21(3):231-8. PMID: 25686104
Reference Series: GSE54979 Sample count: 9
Value type: count Series published: 2015/01/20