DataSet Record GDS5822: Expression Profiles Data Analysis Tools Sample Subsets
Title: Anti-CTLA-4 immunotherapy effect on αSMA+ myofibroblast late-depleted pancreatic ductal adenocarcinoma model
Cluster AnalysisGDS5822 Cluster Image
Summary: Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to deplete αSMA+ myofibroblasts and treated with anti-CTLA4. Results provide insight into molecular basis of anti-CTLA4 therapy in PDAC.
Organism: Mus musculus
Platform: GPL6887: Illumina MouseWG-6 v2.0 expression beadchip
  • Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014 Jun 16;25(6):719-34. PMID: 24856586
Reference Series: GSE52812 Sample count: 9
Value type: count Series published: 2015/01/20