DataSet Record GDS6083: Expression Profiles Data Analysis Tools Sample Subsets
Title: Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins
Cluster AnalysisGDS6083 Cluster Image
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Summary: Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
  • Opel D, Schnaiter A, Dodier D, Jovanovic M et al. Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia. Int J Cancer 2015 Dec 15;137(12):2959-70. PMID: 26096065
Reference Series: GSE62533 Sample count: 12
Value type: transformed count Series published: 2015/03/31