Caspase-1 deficiency effect on lipid-loaded intestines
Summary:
Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
van Diepen JA, Stienstra R, Vroegrijk IO, van den Berg SA et al. Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion. J Lipid Res 2013 Feb;54(2):448-56. PMID: 23160218
