Diabetic nephropathy: models of type 1 and type 2 diabetes
Summary:
Examination of kidneys from streptozotocin-induced diabetic C57BL/6J and db/db animals, which are models for type I and type II diabetes, respectively. Results identify HSD3-beta 4 and OPN as classifiers for the mesangial matrix expansion phenotype, an indicator for end-stage renal disease.
Susztak K, Böttinger E, Novetsky A, Liang D et al. Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes 2004 Mar;53(3):784-94. PMID: 14988265
