Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Anthony Iovene; Yuwen Zhao; Shue Wang; Kagya Amoako

doi:10.3390/jfb12010014

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

J Funct Biomater. 2021 Feb 20;12(1):14. doi: 10.3390/jfb12010014.

Authors

Anthony Iovene^{1

2}, Yuwen Zhao^{1

2}, Shue Wang^{1

2}, Kagya Amoako^{1

2

3}

Affiliations

¹ Biomedical Engineering Graduate Program, Tagliatela College of Engineering, Biomedical Engineering Faculty, University of New Haven, 300 Boston Post Rd., West Haven, CT 06516, USA.
² Department of Mechanical, Industrial and Biomedical Engineering, Tagliatela College of Engineering, Biomedical Engineering Faculty, University of New Haven, 300 Boston Post Rd., West Haven, CT 06516, USA.
³ Biomaterials and Medical Device Innovation Laboratory, Tagliatela College of Engineering, Biomedical Engineering Faculty, University of New Haven, 300 Boston Post Rd., West Haven, CT 06516, USA.

Abstract

Biopolymers are widely accepted natural materials in regenerative medicine, and further development of their bioactivities and discoveries on their composition/function relationships could greatly advance the field. However, a concise insight on commonly investigated biopolymers, their current applications and outlook of their modifications for multibioactivity are scarce. This review bridges this gap for professionals and especially freshmen in the field who are also interested in modification methods not yet in commercial use. A series of polymeric materials in research and development uses are presented as well as challenges that limit their efficacy in tissue regeneration are discussed. Finally, their roles in the regeneration of select tissues including the skin, bone, cartilage, and tendon are highlighted along with modifiable biopolymer moieties for different bioactivities.

Keywords: bioactivity; biopolymers; polymer modification; regenerative medicine; tissue regeneration.

Publication types

Review