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    Thoc2l THO complex subunit 2-like [ Mus musculus (house mouse) ]

    Gene ID: 100042165, updated on 8-Mar-2024

    Summary

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    Official Symbol
    Thoc2lprovided by MGI
    Official Full Name
    THO complex subunit 2-likeprovided by MGI
    Primary source
    MGI:MGI:3040669
    See related
    Ensembl:ENSMUSG00000097392 AllianceGenome:MGI:3040669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm3179; AI451450; 1110004B06Rik; D930016D06Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in neuron development; poly(A)+ mRNA export from nucleus; and viral mRNA export from host cell nucleus. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.9), CNS E14 (RPKM 1.4) and 28 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Thoc2l in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104656172..104702073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104508350..104554207)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Spp1 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_13825 Neighboring gene secreted phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_13829 Neighboring gene STARR-seq mESC enhancer starr_13830 Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene STARR-positive B cell enhancer ABC_E4770 Neighboring gene STARR-seq mESC enhancer starr_13832 Neighboring gene zinc finger protein 33B Neighboring gene predicted gene, 54331 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene predicted gene, 31255

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
    2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in generation of neurons ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100042165

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166581.2 → NP_001160053.1  uncharacterized protein LOC100042165

      Status: VALIDATED

      Source sequence(s)
      AC123687
      Consensus CDS
      CCDS51580.1
      UniProtKB/TrEMBL
      E9Q5E2
      Related
      ENSMUSP00000159295.2, ENSMUST00000239420.2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    RNA

    1. NR_164628.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC123687

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      104656172..104702073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164675.1 → XP_036020568.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    2. XM_036164678.1 → XP_036020571.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    3. XM_036164679.1 → XP_036020572.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    4. XM_036164676.1 → XP_036020569.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    5. XM_036164673.1 → XP_036020566.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    6. XM_036164672.1 → XP_036020565.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    7. XM_036164677.1 → XP_036020570.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Related
      ENSMUSP00000130629.2, ENSMUST00000096452.7
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus

    8. XM_036164674.1 → XP_036020567.1  uncharacterized protein LOC100042165 isoform X1

      UniProtKB/TrEMBL
      E9Q5E2
      Conserved Domains (3) summary
      pfam11262
      Location:874 → 1173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568 → 642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:13 → 566
      THOC2_N; THO complex subunit 2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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