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    MAP2K5 mitogen-activated protein kinase kinase 5 [ Ovis aries (sheep) ]

    Gene ID: 101104069, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MAP2K5
    Gene description
    mitogen-activated protein kinase kinase 5
    See related
    EnsemblRapid:ENSOARG00020009665
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See MAP2K5 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (14352488..14616320)

    Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 30-like Neighboring gene chromosome 7 C15orf61 homolog Neighboring gene U6 spliceosomal RNA Neighboring gene SKI family transcriptional corepressor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      14352488..14616320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042252082.2 → XP_042108016.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

      Conserved Domains (2) summary
      cd06619
      Location:135 → 385
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
      cl02720
      Location:16 → 78
      PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

    2. XM_027971523.2 → XP_027827324.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X10

      Related
      ENSOARP00020013581.2, ENSOART00020016422.2

    3. XM_042252077.1 → XP_042108011.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 414
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    4. XM_027971522.2 → XP_027827323.2  dual specificity mitogen-activated protein kinase kinase 5 isoform X7

      UniProtKB/TrEMBL
      A0A6P3E5U2, W5QAG1
      Related
      ENSOARP00020012468.2, ENSOART00020015059.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 442
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    5. XM_042252078.1 → XP_042108012.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 405
      PKc_like; Protein Kinases, catalytic domain

    6. XM_042252084.1 → XP_042108018.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X8

      Related
      ENSOARP00020013209.2, ENSOART00020015966.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 433
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    7. XM_042252081.1 → XP_042108015.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 394
      PKc_like; Protein Kinases, catalytic domain

    8. XM_042252079.1 → XP_042108013.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 404
      PKc_like; Protein Kinases, catalytic domain

    9. XM_004010260.5 → XP_004010309.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X9

      See identical proteins and their annotated locations for XP_004010309.1

      Related
      ENSOARP00020012602.2, ENSOART00020015231.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cd06619
      Location:164 → 432
      PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

    10. XM_042252083.1 → XP_042108017.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X6

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 384
      PKc_like; Protein Kinases, catalytic domain

    11. XM_042252085.2 → XP_042108019.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X12

      Related
      ENSOARP00020013737.2, ENSOART00020016624.2
      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 378
      PKc_like; Protein Kinases, catalytic domain

    12. XM_042252086.2 → XP_042108020.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X13

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 369
      PKc_like; Protein Kinases, catalytic domain

    13. XM_042252087.2 → XP_042108021.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X14

      Conserved Domains (2) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      cl21453
      Location:164 → 368
      PKc_like; Protein Kinases, catalytic domain

    14. XM_060418889.1 → XP_060274872.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X12

      Related
      ENSOARP00020012320.2, ENSOART00020014886.2

    15. XM_012180834.5 → XP_012036224.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X11

      See identical proteins and their annotated locations for XP_012036224.1

      Related
      ENSOARP00020013385.1, ENSOART00020016180.2
      Conserved Domains (3) summary
      cd06395
      Location:17 → 107
      PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
      smart00221
      Location:166 → 400
      STYKc; Protein kinase; unclassified specificity
      cl21453
      Location:164 → 368
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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