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    Nbn nibrin [ Arvicola amphibius (Eurasian water vole) ]

    Gene ID: 119826828, updated on 21-Mar-2024

    Summary

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    Gene symbol
    Nbn
    Gene description
    nibrin
    See related
    EnsemblRapid:ENSAAPG00005011471
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Arvicola amphibius
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Arvicolinae; Arvicola
    Orthologs
    human mouse all
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    Genomic context

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    See Nbn in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current mArvAmp1.2 (GCF_903992535.2) 11 NC_052057.2 (121759272..121788718)
    100 previous assembly mArvAmp1.1 (GCF_903992535.1) 11 NC_052057.1 (57602864..57632312, complement)

    Chromosome 11 - NC_052057.2Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene 2,4-dienoyl-CoA reductase 1 Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene uncharacterized LOC119826832 Neighboring gene receptor interacting serine/threonine kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nibrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Arvicola amphibius Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mArvAmp1.2

    Genomic

    1. NC_052057.2 Reference mArvAmp1.2

      Range
      121759272..121788718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038348325.2 → XP_038204253.1  nibrin isoform X1

      Related
      ENSAAPP00005014738.1, ENSAAPT00005016150.2
      Conserved Domains (4) summary
      cd00060
      Location:1 → 109
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd17741
      Location:111 → 184
      BRCT_nibrin; BRCT domain of nibrin and similar proteins
      pfam08599
      Location:681 → 742
      Nbs1_C; DNA damage repair protein Nbs1
      pfam16508
      Location:217 → 325
      NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein

    2. XM_038348326.1 → XP_038204254.1  nibrin isoform X2

      Conserved Domains (3) summary
      cd17741
      Location:29 → 102
      BRCT_nibrin; BRCT domain of nibrin and similar proteins
      pfam08599
      Location:599 → 660
      Nbs1_C; DNA damage repair protein Nbs1
      pfam16508
      Location:135 → 243
      NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein

    3. XM_038348327.2 → XP_038204255.1  nibrin isoform X2

      Conserved Domains (3) summary
      cd17741
      Location:29 → 102
      BRCT_nibrin; BRCT domain of nibrin and similar proteins
      pfam08599
      Location:599 → 660
      Nbs1_C; DNA damage repair protein Nbs1
      pfam16508
      Location:135 → 243
      NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein
    Nucleotide Protein
    Heading Accession and Version

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