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    ACA1_369010 polymerase (DNA directed), epsilon, putative [ Acanthamoeba castellanii str. Neff ]

    Gene ID: 14919099, updated on 17-May-2024

    Summary

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    Gene symbol
    ACA1_369010
    Gene description
    polymerase (DNA directed), epsilon, putative
    Primary source
    AmoebaDB:ACA1_369010
    Locus tag
    ACA1_369010
    See related
    VEuPathDB:ACA1_369010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Acanthamoeba castellanii str. Neff (strain: Neff, culture-collection: ATCC:30010)
    Lineage
    Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida; Acanthamoebidae; Acanthamoeba
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    Genomic context

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    See ACA1_369010 in Genome Data Viewer
    Location:
    chromosome: Unknown
    Exon count:
    45

    NW_004457466.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene peroxidase Neighboring gene acetyltransferase, GNAT family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004457466.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Clarke M, et al. Genome Biol, 2013 Feb 1. PMID 23375108, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA 3'-5' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA replication proofreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, gap-filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leading strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polymerase (DNA directed), epsilon, putative
    XP_004340189.1
    • encoded by transcript ACA1_369010A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_004457466.1 Reference assembly

      Range
      214305..224104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004340141.1 → XP_004340189.1  polymerase (DNA directed), epsilon, putative [Acanthamoeba castellanii str. Neff]

      See identical proteins and their annotated locations for XP_004340189.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      L8GY46
      Conserved Domains (4) summary
      cd05779
      Location:189 → 386
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      COG0417
      Location:65 → 1086
      PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
      cl10023
      Location:445 → 1075
      POLBc; DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic ...
      pfam08490
      Location:1494 → 1876
      DUF1744; Domain of unknown function (DUF1744)
    Nucleotide Protein
    Heading Accession and Version

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