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    ADIPOQ adiponectin, C1Q and collagen domain containing [ Bos taurus (cattle) ]

    Gene ID: 282865, updated on 6-Jun-2024

    Summary

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    Official Symbol
    ADIPOQprovided by VGNC
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by VGNC
    Primary source
    VGNC:VGNC:25677
    See related
    BGD:BT11980; Ensembl:ENSBTAG00000059085
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADID; APM1; ACRP30
    Orthologs
    human mouse all
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    Genomic context

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    See ADIPOQ in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (80414393..80427598, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-2285k-3 Neighboring gene STARD3 N-terminal-like protein Neighboring gene small nucleolar RNA SNORA4 Neighboring gene replication factor C subunit 4 Neighboring gene eukaryotic translation initiation factor 4A2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of hormonal and energy-related factors on plasma adiponectin in transition dairy cows. Krumm CS, et al. J Dairy Sci, 2017 Nov. PMID 28843695
    2. Characterization of adiponectin concentrations and molecular weight forms in serum, seminal plasma, and ovarian follicular fluid from cattle. Heinz JF, et al. Theriogenology, 2015 Feb. PMID 25468552
    3. Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows. Singh SP, et al. Domest Anim Endocrinol, 2014 Apr. PMID 24462180
    4. Identification and genetic effect of a variable duplication in the promoter region of the cattle ADIPOQ gene. Zhang L, et al. Anim Genet, 2014 Apr. PMID 24341634
    5. Haplotype combination of polymorphisms in the ADIPOQ gene promoter is associated with growth traits in Qinchuan cattle. Zhang L, et al. Genome, 2013 Jul. PMID 24099391

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that energy balance around parturition may regulate plasma adiponectin but do not support roles for lipid mobilization or sustained changes in the plasma concentration of leptin, insulin, growth hormone, or fatty acids.
      Title: Effect of hormonal and energy-related factors on plasma adiponectin in transition dairy cows.
    2. Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 and AdipoR2 mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.
      Title: Characterisation of adiponectin and its receptors in the bovine mammary gland and in milk.
    3. Data suggest that genetic variation in promoter region of ADIPOQ (SNPs g.81966235C>T, g.81966377T>C, and g.81966364D>I) contribute to adiposity/marbling in skeletal muscle/meat (and thus meat quality) of Hanwoo beef cattle of North Korea.
      Title: Effects of genetic variants in the promoter region of the bovine adiponectin (ADIPOQ) gene on marbling of Hanwoo beef cattle.
    4. These data suggest differential contribution of adipose tissue depots to circulating adiponectin.
      Title: Lactation driven dynamics of adiponectin supply from different fat depots to circulation in cows.
    5. Association analysis indicated that variable duplication within the ADIPOQ gene is associated with body measurements.
      Title: Identification and genetic effect of a variable duplication in the promoter region of the cattle ADIPOQ gene.
    6. 14 polymorphisms of the ADIPOQ gene were observed in Chinese cattle; 2 polymorphisms PR_-135 A>G and PR_-68 G>C were located in the core promoter region of ADIPOQ; 3 haplotypes in the 2 polymorphic sites were detected which produce effects on ADIPOQ transcription and are associated with growth traits
      Title: Haplotype combination of polymorphisms in the ADIPOQ gene promoter is associated with growth traits in Qinchuan cattle.
    7. reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance
      Title: Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows.
    8. The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.
      Title: Changes in the gene expression of adiponectin and adiponectin receptors (AdipoR1 and AdipoR2) in ovarian follicular cells of dairy cow at different stages of development.
    9. The disulfide bonds help to maintain the mature octadecameric adiponectin structure and stabilize intermediates during the assembly.
      Title: Disulfide-dependent self-assembly of adiponectin octadecamers from trimers and presence of stable octadecameric adiponectin lacking disulfide bonds in vitro.
    10. Adiponectin gene was proved to be closely related to carcass and meat quality traits (P < 0.05), which can be used as a candidate molecular marker for production of high-grade meat in Qinchuan beef cattle.
      Title: [SNPs detection of adiponectin gene and its relationship with carcass and meat quality traits in Qinchuan cattle].
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

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    Homology

    Clone Names

    • MGC138982

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adiponectin
    Names
    30 kDa adipocyte complement-related protein
    adipocyte complement related 30kDa protein
    adipocyte complement related protein of 30 kDa
    adipocyte complement-related 30 kDa protein
    adipocyte, C1q and collagen domain-containing protein
    adiponectin D
    adipose most abundant gene transcript 1 protein
    apM-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174742.2 → NP_777167.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_777167.1

      Status: PROVISIONAL

      Source sequence(s)
      AF269230
      UniProtKB/Swiss-Prot
      Q3Y5Z3
      Conserved Domains (2) summary
      smart00110
      Location:104 → 237
      C1Q; Complement component C1q domain
      pfam01391
      Location:37 → 99
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      80414393..80427598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024995232.2 → XP_024851000.1  adiponectin isoform X1

      UniProtKB/Swiss-Prot
      A5D7A8, Q3Y5Z3, Q95MQ4
      UniProtKB/TrEMBL
      A0A3B0J3V0
      Related
      ENSBTAP00000087044.1, ENSBTAT00000135305.1
      Conserved Domains (2) summary
      smart00110
      Location:101 → 237
      C1Q; Complement component C1q domain
      pfam01391
      Location:46 → 101
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_015472143.1 → XP_015327629.1  adiponectin isoform X2

      UniProtKB/TrEMBL
      A0AAA9TX29
      Related
      ENSBTAP00000102914.1, ENSBTAT00000118816.1
      Conserved Domains (2) summary
      smart00110
      Location:107 → 243
      C1Q; Complement component C1q domain
      pfam01391
      Location:52 → 107
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3Y5Z3.1 GenPept UniProtKB/Swiss-Prot:Q3Y5Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials