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    Kcp kielin/chordin-like protein [ Mus musculus (house mouse) ]

    Gene ID: 333088, updated on 12-May-2024

    Summary

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    Official Symbol
    Kcpprovided by MGI
    Official Full Name
    kielin/chordin-like proteinprovided by MGI
    Primary source
    MGI:MGI:2141640
    See related
    Ensembl:ENSMUSG00000059022 AllianceGenome:MGI:2141640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crim2; Gm793; KCP-1; CRIM-2
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation and positive regulation of BMP signaling pathway. Located in extracellular space. Orthologous to human KCP (kielin cysteine rich BMP regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 11.6), ovary adult (RPKM 5.1) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcp in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29473161..29508006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29473162..29508003, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene filamin C, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr6:29417613-29417914 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit F Neighboring gene sperm microtubule inner protein 1 Neighboring gene predicted gene, 26627 Neighboring gene STARR-positive B cell enhancer ABC_E3647 Neighboring gene STARR-seq mESC enhancer starr_15441 Neighboring gene interferon regulatory factor 5 Neighboring gene transportin 3 Neighboring gene STARR-seq mESC enhancer starr_15442 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559591-29559700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559883-29560036 Neighboring gene STARR-seq mESC enhancer starr_15443 Neighboring gene STARR-seq mESC enhancer starr_15447 Neighboring gene STARR-positive B cell enhancer ABC_E6419 Neighboring gene STARR-seq mESC enhancer starr_15449 Neighboring gene predicted gene, 30896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. Soofi A, et al. J Biol Chem, 2017 Jun 2. PMID 28424263, Free PMC Article
    2. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. Soofi A, et al. Am J Physiol Gastrointest Liver Physiol, 2016 Oct 1. PMID 27514479, Free PMC Article
    3. Kielin/chordin-like protein attenuates both acute and chronic renal injury. Soofi A, et al. J Am Soc Nephrol, 2013 May. PMID 23539757, Free PMC Article
    4. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Lin J, et al. Mol Cell Biol, 2006 Jun. PMID 16738323, Free PMC Article
    5. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Lin J, et al. Nat Med, 2005 Apr. PMID 15793581

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
      Title: Kielin/chordin-like protein deficiency aggravates pressure overload-induced cardiac dysfunction and remodeling via P53/P21/CCNB1 signaling in mice.
    2. Kielin/chordin-like protein deficiency causes cardiac aging in male mice.
      Title: Kielin/chordin-like protein deficiency causes cardiac aging in male mice.
    3. Metabolic profiling indicated increased energy expenditure in KCP-overexpressing mice and reduced expenditure in the KCP mutants with no effect on food intake or activity. These findings demonstrate that shifting the TGF-beta superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet.
      Title: The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice.
    4. These data suggest that extracellular regulation of the TGF-beta/BMP signaling axis by KCP, and by extension possibly other cysteine-rich domain proteins, can attenuate both acute and chronic renal injury.
      Title: Kielin/chordin-like protein attenuates both acute and chronic renal injury.
    5. role for KCP in modulating the responses between these anti- and profibrotic cytokines in the initiation and progression of renal interstitial fibrosis
      Title: The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia.
    6. The data indicate an important role for KCP in attenuating the pathology of renal fibrotic disease.
      Title: Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kielin/chordin-like protein
    Names
    cysteine rich BMP regulator 2 (chordin like)
    cysteine-rich BMP regulator 2
    cysteine-rich motor neuron 2 protein
    kielin/chordin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029985.4 → NP_001025156.3  kielin/chordin-like protein precursor

      See identical proteins and their annotated locations for NP_001025156.3

      Status: VALIDATED

      Source sequence(s)
      AC079276, BC059023
      Consensus CDS
      CCDS57415.1
      UniProtKB/Swiss-Prot
      E9QJU0, Q3U492, Q56NI8
      UniProtKB/TrEMBL
      E9QNB3
      Related
      ENSMUSP00000099135.4, ENSMUST00000101614.10
      Conserved Domains (5) summary
      pfam00093
      Location:136 → 190
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1214 → 1363
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1489 → 1542
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1407 → 1478
      C8; C8 domain
      cl17735
      Location:428 → 484
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29473161..29508006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241070.4 → XP_011239372.1  kielin/chordin-like protein isoform X8

      Conserved Domains (6) summary
      smart00214
      Location:1221 → 1278
      VWC; von Willebrand factor (vWF) type C domain
      pfam00093
      Location:166 → 220
      VWC; von Willebrand factor type C domain
      cl17735
      Location:634 → 690
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1285 → 1432
      VWD; von Willebrand factor type D domain
      pfam03157
      Location:1757 → 1975
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam08742
      Location:1482 → 1549
      C8; C8 domain

    2. XM_011241071.3 → XP_011239373.1  kielin/chordin-like protein isoform X1

      Conserved Domains (5) summary
      pfam00093
      Location:166 → 220
      VWC; von Willebrand factor type C domain
      cl17735
      Location:458 → 514
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1285 → 1432
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1560 → 1613
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1482 → 1549
      C8; C8 domain

    3. XM_017321660.3 → XP_017177149.1  kielin/chordin-like protein isoform X2

      Conserved Domains (5) summary
      pfam00093
      Location:136 → 190
      VWC; von Willebrand factor type C domain
      cl17735
      Location:428 → 484
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1255 → 1402
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1530 → 1583
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1452 → 1519
      C8; C8 domain

    4. XM_017321661.3 → XP_017177150.1  kielin/chordin-like protein isoform X4

      Conserved Domains (5) summary
      pfam00093
      Location:166 → 220
      VWC; von Willebrand factor type C domain
      cl17735
      Location:458 → 514
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1243 → 1390
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1518 → 1571
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1440 → 1507
      C8; C8 domain

    5. XM_006505131.4 → XP_006505194.1  kielin/chordin-like protein isoform X3

      Conserved Domains (5) summary
      pfam00093
      Location:166 → 220
      VWC; von Willebrand factor type C domain
      cl17735
      Location:458 → 514
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1244 → 1391
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1519 → 1572
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1441 → 1508
      C8; C8 domain

    6. XM_030255489.2 → XP_030111349.1  kielin/chordin-like protein isoform X6

      Conserved Domains (5) summary
      smart00214
      Location:845 → 902
      VWC; von Willebrand factor (vWF) type C domain
      cl17735
      Location:82 → 138
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:909 → 1056
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1184 → 1237
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1106 → 1173
      C8; C8 domain

    7. XM_017321663.3 → XP_017177152.1  kielin/chordin-like protein isoform X5

      Conserved Domains (4) summary
      cl17735
      Location:277 → 333
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:1104 → 1251
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:1379 → 1432
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1301 → 1368
      C8; C8 domain

    8. XM_006505134.5 → XP_006505197.1  kielin/chordin-like protein isoform X7

      Conserved Domains (1) summary
      cl17735
      Location:166 → 220
      VWC; von Willebrand factor type C domain

    RNA

    1. XR_868761.4 RNA Sequence

    2. XR_003956221.2 RNA Sequence

    3. XR_003956220.2 RNA Sequence

    4. XR_003956222.2 RNA Sequence

      Related
      ENSMUST00000091391.11

    5. XR_004942978.1 RNA Sequence

    6. XR_868762.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U492.2 GenPept UniProtKB/Swiss-Prot:Q3U492

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