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    CG8677 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35397, updated on 10-May-2024

    Summary

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    Official Symbol
    CG8677provided by FlyBase
    Primary source
    FLYBASE:FBgn0026577
    Locus tag
    Dmel_CG8677
    See related
    AllianceGenome:FB:FBgn0026577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD14959; BEST:LD19244; Dmel\CG8677; dRsf-1; LD14959; rsf-1
    Summary
    Predicted to enable histone binding activity and transcription coregulator activity. Involved in histone exchange. Located in nucleus. Part of RSF complex. Colocalizes with euchromatin. Is expressed in organism and spermatozoon. Orthologous to human RSF1 (remodeling and spacing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG8677 in Genome Data Viewer
    Location:
    39B3-39B3; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21221312..21232059)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21221312..21232059)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U4 at 39B Neighboring gene Autophagy-related 18b Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein Neighboring gene mir-9374 stem loop Neighboring gene Hormone receptor-like in 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active promoters give rise to false positive 'Phantom Peaks' in ChIP-seq experiments. Jain D, et al. Nucleic Acids Res, 2015 Aug 18. PMID 26117547, Free PMC Article
    2. HBXAP, a novel PHD-finger protein, possesses transcription repression activity. Shamay M, et al. Genomics, 2002 Apr. PMID 11944984
    3. RSF governs silent chromatin formation via histone H2Av replacement. Hanai K, et al. PLoS Genet, 2008 Feb 29. PMID 18454204, Free PMC Article
    4. Application of the gene search system to screen for longevity genes in Drosophila. Seong KH, et al. Biogerontology, 2001. PMID 11708722
    5. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RSF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RSF complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8677-PB
    CG8677-PC
    HBXAP ortholog
    remodeling and spacing factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21221312..21232059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299194.1 → NP_001286123.1  uncharacterized protein Dmel_CG8677, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VID9
      Conserved Domains (3) summary
      pfam09528
      Location:770 → 1243
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd15543
      Location:1373 → 1419
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam12067
      Location:2107 → 2186
      Sox_C_TAD; Sox C-terminal transactivation domain

    2. NM_136257.4 → NP_610101.3  uncharacterized protein Dmel_CG8677, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610101.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VID9
      Conserved Domains (3) summary
      pfam09528
      Location:770 → 1243
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      cd15543
      Location:1373 → 1419
      PHD_RSF1; PHD finger found in Remodeling and spacing factor 1 (Rsf-1)
      pfam12067
      Location:2107 → 2186
      Sox_C_TAD; Sox C-terminal transactivation domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IH15 Q8IH15
    Q8SWR4 Q8SWR4
    Q8SXA3 Q8SXA3
    Q9VID9 Q9VID9

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