Mcad Medium-chain acyl-CoA dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mcadprovided by FlyBase
Official Full Name: Medium-chain acyl-CoA dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035811
Locus tag: Dmel_CG12262
See related: AllianceGenome:FB:FBgn0035811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ACAD; CG 12262; CG12262; Dmel\CG12262; mcad; MCAD
Summary: Enables medium-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including circulatory system; epithelium; gastrula embryo; gut section; and yolk nucleus. Used to study medium chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 66A10-66A10; 3-21 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7719350..7721472)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7712450..7714572)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PINK1 mediates the phosphorylation of MCAD, a mitochondrial matrix protein critical to fatty acid metabolism.
Title: Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Medium-chain acyl-CoA dehydrogenase

Names: CG12262-PA; Mcad-PA; acyl-CoA dehdrogenase; medium chain acyl-CoA dehydrogenase; medium-chain acyl-coenzyme A dehydrogenase; probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial

NP_648149.1

EC 1.3.-.-

EC 1.3.8.7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

7719350..7721472

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139892.3 → NP_648149.1 Medium-chain acyl-CoA dehydrogenase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648149.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VSA3

UniProtKB/TrEMBL

G3KKP7

Related

FBpp0076520

Conserved Domains (2) summary

cd01157
Location:37 → 414

MCAD; Medium chain acyl-CoA dehydrogenase

COG1960
Location:35 → 411

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]