U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    smp-30 Senescence marker protein-30 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41786, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    smp-30provided by FlyBase
    Official Full Name
    Senescence marker protein-30provided by FlyBase
    Primary source
    FLYBASE:FBgn0038257
    Locus tag
    Dmel_CG7390
    See related
    AllianceGenome:FB:FBgn0038257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7390; CT22723; Dca; Dmel\CG7390; Smp-30
    Summary
    Enables serine hydrolase activity. Involved in cold acclimation; negative regulation of imaginal disc-derived wing size; and regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis. Predicted to be located in cytosol. Is expressed in adult head; adult heart; amnioserosa; and yolk nucleus. Orthologous to human RGN (regucalcin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See smp-30 in Genome Data Viewer
    Location:
    88D2-88D2; 3-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14745901..14751246, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10571623..10576968, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene effete Neighboring gene javelin-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene. Lee SF, et al. Mol Biol Evol, 2011 Aug. PMID 21393605
    2. Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila. Clowers KJ, et al. Genet Res (Camb), 2010 Apr. PMID 20515514
    3. Expression of Drosophila homologue of senescence marker protein-30 during cold acclimation. Goto SG. J Insect Physiol, 2000 Jul 1. PMID 10817837
    4. The Dca gene involved in cold adaptation in Drosophila melanogaster arose by duplication of the ancestral regucalcin gene. Arboleda-Bustos CE, et al. Mol Biol Evol, 2011 Aug. PMID 21339509
    5. A clinally varying promoter polymorphism associated with adaptive variation in wing size in Drosophila. McKechnie SW, et al. Mol Ecol, 2010 Feb. PMID 20074315

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular evolution of Dca has been affected by its implication in the adaptive response to cold temperatures.
      Title: The Dca gene involved in cold adaptation in Drosophila melanogaster arose by duplication of the ancestral regucalcin gene.
    2. Dca is a candidate for climatic adaptation in D. melanogaster.
      Title: Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence analyses of the Dca gene.
    3. Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila
      Title: Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in cold acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    senescence marker protein-30
    Names
    CG7390-PA
    CG7390-PB
    CG7390-PC
    CG7390-PD
    cold acclimation
    drosophila cold acclimation
    drosophila cold acclimation gene
    smp-30-PA
    smp-30-PB
    smp-30-PC
    smp-30-PD
    NP_001262580.1
    NP_001262581.1
    NP_524353.2
    NP_731942.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14745901..14751246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169602.2 → NP_731942.1  senescence marker protein-30, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9HRV4, D9HRW7, D9HRX4, D9HRZ7, Q9NDS6, Q9VFG5
      Related
      FBpp0082476
      Conserved Domains (3) summary
      cd05819
      Location:165 → 205
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:165 → 245
      NHL; NHL repeat unit of beta-propeller proteins

    2. NM_001275651.1 → NP_001262580.1  senescence marker protein-30, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9HRV4, D9HRW7, D9HRX4, D9HRZ7, H8F4T3, Q9NDS6
      Conserved Domains (3) summary
      cd05819
      Location:168 → 208
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:18 → 277
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:168 → 248
      NHL; NHL repeat unit of beta-propeller proteins

    3. NM_001275652.1 → NP_001262581.1  senescence marker protein-30, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9HRV4, D9HRW7, D9HRX4, D9HRZ7, Q9NDS6, Q9VFG5
      Conserved Domains (3) summary
      cd05819
      Location:165 → 205
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:165 → 245
      NHL; NHL repeat unit of beta-propeller proteins

    4. NM_079629.4 → NP_524353.2  senescence marker protein-30, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524353.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9HRV4, D9HRW7, D9HRX4, D9HRZ7, Q9NDS6, Q9VFG5
      Related
      FBpp0082475
      Conserved Domains (3) summary
      cd05819
      Location:165 → 205
      NHL; NHL repeat [structural motif]
      pfam08450
      Location:15 → 274
      SGL; SMP-30/Gluconolaconase/LRE-like region
      cl18310
      Location:165 → 245
      NHL; NHL repeat unit of beta-propeller proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H8F4T3 H8F4T3
    Q9NDS5 Q9NDS5
    Q9NDS6 Q9NDS6
    Q9VFG5 Q9VFG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous