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    PDGFB platelet derived growth factor subunit B [ Ovis aries (sheep) ]

    Gene ID: 443545, updated on 3-Apr-2024

    Summary

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    Gene symbol
    PDGFB
    Gene description
    platelet derived growth factor subunit B
    See related
    EnsemblRapid:ENSOARG00020012236
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFB in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (216485165..216505201, complement)

    Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F Neighboring gene uncharacterized LOC132659640 Neighboring gene chromobox 7 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene small nucleolar RNA U83B Neighboring gene ribosomal protein L3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit B
    Names
    PDGF subunit B
    PDGF-2
    platelet-derived growth factor B chain
    platelet-derived growth factor B subunit
    platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009471.1 → NP_001009471.1  platelet-derived growth factor subunit B precursor

      See identical proteins and their annotated locations for NP_001009471.1

      Status: PROVISIONAL

      Source sequence(s)
      X97123
      UniProtKB/Swiss-Prot
      Q95229
      UniProtKB/TrEMBL
      W5Q4I1
      Related
      ENSOARP00020015558.2, ENSOART00020018791.2
      Conserved Domains (2) summary
      pfam00341
      Location:97 → 180
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      216485165..216505201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027965772.3 → XP_027821573.1  platelet-derived growth factor subunit B isoform X2

      UniProtKB/TrEMBL
      A0A6P7DS29, W5Q4I1
      Conserved Domains (2) summary
      pfam00341
      Location:98 → 181
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:21 → 94
      PDGF_N; Platelet-derived growth factor, N terminal region

    2. XM_027965771.3 → XP_027821572.1  platelet-derived growth factor subunit B isoform X1

      UniProtKB/TrEMBL
      W5Q4I1
      Related
      ENSOARP00020047838.1, ENSOART00020052398.1

    3. XM_060411618.1 → XP_060267601.1  platelet-derived growth factor subunit B isoform X3

      Related
      ENSOARP00020046235.1, ENSOART00020058810.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95229.1 GenPept UniProtKB/Swiss-Prot:Q95229

    Gene LinkOut

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