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    Nup210 nucleoporin 210 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58958, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Nup210provided by RGD
    Official Full Name
    nucleoporin 210provided by RGD
    Primary source
    RGD:69339
    See related
    Ensembl:ENSRNOG00000005390 AllianceGenome:RGD:69339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pom210
    Summary
    Involved in protein-containing complex assembly. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Orthologous to human NUP210 (nucleoporin 210). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 163.7), Thymus (RPKM 115.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup210 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (125068736..125167238, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (123511558..123609874, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122643952..122741322, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene uncharacterized LOC134486814 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486816 Neighboring gene histone deacetylase 11 Neighboring gene fibulin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphomimetic mutation of the mitotically phosphorylated serine 1880 compromises the interaction of the transmembrane nucleoporin gp210 with the nuclear pore complex. Onischenko EA, et al. Exp Cell Res, 2007 Jul 15. PMID 17559836
    2. Biochemical characterization of nuclear pore complex protein gp210 oligomers. Favreau C, et al. Eur J Biochem, 2001 Jul. PMID 11453980
    3. Primary structure analysis of an integral membrane glycoprotein of the nuclear pore. Wozniak RW, et al. J Cell Biol, 1989 Jun. PMID 2738089, Free PMC Article
    4. The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope. Wozniak RW, et al. J Cell Biol, 1992 Dec. PMID 1281815, Free PMC Article
    5. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, et al. J Cell Biol, 1997 Jun 16. PMID 9182656, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings are consistent with the idea that mitotic phosphorylation acts to dissociate gp210 from the structural elements of the nuclear pore complexes.
      Title: Phosphomimetic mutation of the mitotically phosphorylated serine 1880 compromises the interaction of the transmembrane nucleoporin gp210 with the nuclear pore complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear pore membrane glycoprotein 210
    Names
    nuclear envelope pore membrane protein POM 210
    nuclear pore protein gp210
    nucleoporin Nup210
    pore membrane protein of 210 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053322.3 → NP_445774.1  nuclear pore membrane glycoprotein 210 precursor

      See identical proteins and their annotated locations for NP_445774.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P11654
      UniProtKB/TrEMBL
      A6IB90
      Related
      ENSRNOP00000008888.3, ENSRNOT00000008888.5
      Conserved Domains (1) summary
      pfam02368
      Location:1079 → 1152
      Big_2; Bacterial Ig-like domain (group 2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      125068736..125167238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286649.1 → XP_063142719.1  nuclear pore membrane glycoprotein 210 isoform X2

    2. XM_063286648.1 → XP_063142718.1  nuclear pore membrane glycoprotein 210 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11654.1 GenPept UniProtKB/Swiss-Prot:P11654

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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