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    Gabarapl1 GABA type A receptor associated protein like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689161, updated on 2-May-2024

    Summary

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    Official Symbol
    Gabarapl1provided by RGD
    Official Full Name
    GABA type A receptor associated protein like 1provided by RGD
    Primary source
    RGD:1596143
    See related
    AllianceGenome:RGD:1596143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gec1
    Summary
    Predicted to enable GABA receptor binding activity; Tat protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in autophagosome assembly; autophagy of mitochondrion; and cellular response to nitrogen starvation. Located in several cellular components, including Golgi apparatus; cell body; and dendrite. Orthologous to human GABARAPL1 (GABA type A receptor associated protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1335.2), Brain (RPKM 1262.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabarapl1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164666332..164675474)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162980309..162989452)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (163293724..163302866)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52B Neighboring gene uncharacterized LOC102554909 Neighboring gene killer cell lectin like receptor E1 Neighboring gene killer cell lectin like receptor D1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific regional distribution of gec1 mRNAs in adult rat central nervous system. Tolle F, et al. Brain Res, 2008 May 19. PMID 18423580
    2. Distribution and ultrastructural localization of GEC1 in the rat CNS. Wang Y, et al. Neuroscience, 2006 Jul 21. PMID 16650615
    3. Oxidative-Damaged Mitochondria Activate GABARAPL1-Induced NLRP3 Inflammasomes in an Autophagic-Exosome Manner after Acute Myocardial Ischemia. Zhang T, et al. Oxid Med Cell Longev, 2022. PMID 36238641, Free PMC Article
    4. Expression of the GABAA receptor associated protein Gec1 is circadian and dependent upon the cellular clock machinery in GnRH secreting GnV-3 cells. Mansuy V, et al. Mol Cell Endocrinol, 2009 Aug 13. PMID 19524128
    5. Nix, a receptor protein for mitophagy in mammals. Kanki T. Autophagy, 2010 Apr. PMID 20200478

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gec1 expression is dependent upon the circadian clock machinery in GnRH-expressing neurons.
      Title: Expression of the GABAA receptor associated protein Gec1 is circadian and dependent upon the cellular clock machinery in GnRH secreting GnV-3 cells.
    2. the putative role in the trafficking of receptor GABA(A)
      Title: Specific regional distribution of gec1 mRNAs in adult rat central nervous system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125167

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor-associated protein-like 1
    Names
    GABA(A) receptor-associated protein like 1
    GEC-1
    gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 1
    glandular epithelial cell protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044294.1 → NP_001037759.1  gamma-aminobutyric acid receptor-associated protein-like 1

      See identical proteins and their annotated locations for NP_001037759.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105627
      UniProtKB/Swiss-Prot
      Q0VGK0
      UniProtKB/TrEMBL
      A6IM58
      Conserved Domains (1) summary
      cd16127
      Location:5 → 111
      Ubl_ATG8_GABARAP_like; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP) and similar proteins; sub-family of the autophagy-related 8 (ATG8) protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164666332..164675474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VGK0.1 GenPept UniProtKB/Swiss-Prot:Q0VGK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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