Mapk11 mitogen-activated protein kinase 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk11provided by RGD
Official Full Name: mitogen-activated protein kinase 11provided by RGD
Primary source: RGD:1309340
See related: Ensembl:ENSRNOG00000006984 AllianceGenome:RGD:1309340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p38beta
Summary: Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human MAPK11 (mitogen-activated protein kinase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 67.3), Lung (RPKM 23.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122098120..122105023, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120218471..120225488, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130121678..130129199, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Data indicate a functionally active mitochondrial pool of p38beta mitogen activated protein kinase (p38beta MAPK), and that this kinase phosphorylates manganese superoxide dismutase (MnSOD) in an 17beta-estradiol (E2)-dependent manner.
Title: Mitochondrial p38β and manganese superoxide dismutase interaction mediated by estrogen in cardiomyocytes.
p38beta confers protection against hydrogen peroxide (HO)-induced astrocyte apoptosis by inducing a small heat shock protein, alphaB-crystallin, which inhibits caspase-3 activation.
Title: p38β MAPK affords cytoprotection against oxidative stress-induced astrocyte apoptosis via induction of αB-crystallin and its anti-apoptotic function.
Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells.
Title: Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.
p38beta-induced B-natriuretic peptide transcription was mediated by a GATA-4 transcription factor binding site.
Title: Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.
Data shwo that hyperalgesia is prevented by downregulation of p38beta but not p38alpha, whereas increases in spinal COX-2 protein expression at 8 hours are mediated by both p38alpha and beta isoforms.
Title: Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression.
in intestinal epithelial cells, Ang II-dependent activation of the COX-2 promoter is mediated primarily through Gq/11 signaling via a PAK/MKK6/Mapk11/CREB signaling cascade
Title: COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells.
unique ceramide signaling in ischemic and preconditioned hearts involving lipid rafts, which generated a survival signal by differentially associating the p38MAPKalpha and p38MAPKbeta with the caveolin-1 and caveoli-3
Title: Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart.

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General gene information

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Markers

Mapk11 (e-PCR), detects polymorphism
- UniSTS:515955

RH137764 (e-PCR)
- UniSTS:219851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 11

NP_001103002.2

EC 2.7.11.1

XP_017450608.1

EC 2.7.11.1

XP_038935846.1

EC 2.7.11.1

XP_038935847.1

EC 2.7.11.1

XP_063120345.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109532.2 → NP_001103002.2 mitogen-activated protein kinase 11

See identical proteins and their annotated locations for NP_001103002.2

Status: PROVISIONAL

Source sequence(s)

CH474027

UniProtKB/TrEMBL

A0A0G2KB06, A0A8I6G769, A6K7K4

Related

ENSRNOP00000075602.1, ENSRNOT00000079777.2

Conserved Domains (1) summary

cl21453
Location:8 → 350

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122098120..122105023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595119.3 → XP_017450608.1 mitogen-activated protein kinase 11 isoform X1

UniProtKB/TrEMBL

A0A8I6G769, B1WC76, D4A3U7

Related

ENSRNOP00000009325.6
XM_063264275.1 → XP_063120345.1 mitogen-activated protein kinase 11 isoform X2
XM_039079918.2 → XP_038935846.1 mitogen-activated protein kinase 11 isoform X3

Conserved Domains (1) summary

cl21453
Location:8 → 234

PKc_like; Protein Kinases, catalytic domain
XM_039079919.2 → XP_038935847.1 mitogen-activated protein kinase 11 isoform X4

Conserved Domains (1) summary

cl21453
Location:8 → 210

PKc_like; Protein Kinases, catalytic domain