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    MAMU-DRA major histocompatibility complex, class II, DR alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 100187587, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MAMU-DRA
    Gene description
    major histocompatibility complex, class II, DR alpha
    Locus tag
    EGK_14758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    DRA; HLA-DRA; DR-alpha; Mamu-DRA1
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (137076488..137081619, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (33284417..33289554)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene HLA class II histocompatibility antigen, DRB1-4 beta chain Neighboring gene DLA class II histocompatibility antigen, DR-1 beta chain-like Neighboring gene uncharacterized LOC114677632 Neighboring gene U6 spliceosomal RNA Neighboring gene testis expressed basic protein 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and molecular characterization of rhesus monkey major histocompatibility complex class II DR. Lekutis C, et al. Hum Immunol, 1995 May. PMID 7558932
    2. Reshuffling of ancient peptide binding motifs between HLA-DRB multigene family members: old wine served in new skins. Doxiadis GG, et al. Mol Immunol, 2008 May. PMID 18395261
    3. Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenes. de Groot N, et al. J Immunol, 2004 May 15. PMID 15128802
    4. Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques. Deng Q, et al. Immunogenetics, 2013 Dec. PMID 24042461

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mamu class II histocompatibility antigen, DR alpha chain
    Names
    HLA class II histocompatibility antigen, DR alpha chain
    MHC class II DRA
    MHC class II antigen DRA
    Mamu class II histocompatibility antigen, DR alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134298.1 → NP_001127770.1  mamu class II histocompatibility antigen, DR alpha chain precursor

      See identical proteins and their annotated locations for NP_001127770.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ586874
      UniProtKB/TrEMBL
      Q6EWK6, Q6EWL5, S0ES10, S0ES13, S0ETR9
      Conserved Domains (3) summary
      pfam00993
      Location:29 → 106
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cd00096
      Location:111 → 119
      Ig; Ig strand A [structural motif]
      cl11960
      Location:110 → 204
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      137076488..137081619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015135912.2 → XP_014991398.2  mamu class II histocompatibility antigen, DR alpha chain isoform X1

      UniProtKB/Swiss-Prot
      Q30631
      UniProtKB/TrEMBL
      Q6EWK7, S0ES10
      Conserved Domains (2) summary
      cd05767
      Location:111 → 204
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:29 → 106
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q30631.1 GenPept UniProtKB/Swiss-Prot:Q30631

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