Rita1 RBPJ interacting and tubulin associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rita1provided by MGI
Official Full Name: RBPJ interacting and tubulin associated 1provided by MGI
Primary source: MGI:MGI:1922021
See related: Ensembl:ENSMUSG00000029600 AllianceGenome:MGI:1922021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rita; 1110008J03Rik
Summary: Predicted to enable tubulin binding activity. Predicted to be involved in negative regulation of Notch signaling pathway and nuclear export. Predicted to act upstream of or within Notch signaling pathway and nervous system development. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human RITA1 (RBPJ interacting and tubulin associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 13.5), stomach adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 60.63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120747123..120750654, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120609058..120612589, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J.
Title: Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

AI853657 (e-PCR)
- UniSTS:165425

C86297 (e-PCR)
- UniSTS:207866

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nuclear export	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RBPJ-interacting and tubulin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029096.3 → NP_083372.1 RBPJ-interacting and tubulin-associated protein 1

See identical proteins and their annotated locations for NP_083372.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC125183, AI850520, AK003581

Consensus CDS

CCDS51635.1

UniProtKB/Swiss-Prot

Q9D1H0

Related

ENSMUSP00000031599.3, ENSMUST00000031599.9

Conserved Domains (1) summary

pfam17066
Location:1 → 253

RITA; RBPJ-interacting and tubulin associated protein
NM_133908.1 → NP_598669.1 RBPJ-interacting and tubulin-associated protein 1

See identical proteins and their annotated locations for NP_598669.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC125183, CX239969

Consensus CDS

CCDS51635.1

UniProtKB/Swiss-Prot

Q9D1H0

Related

ENSMUSP00000136946.2, ENSMUST00000177800.8

Conserved Domains (1) summary

pfam17066
Location:1 → 253

RITA; RBPJ-interacting and tubulin associated protein