Cplx2 complexin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cplx2provided by RGD
Official Full Name: complexin 2provided by RGD
Primary source: RGD:70945
See related: Ensembl:ENSRNOG00000000105 AllianceGenome:RGD:70945
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynapse and presynapse. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1041.7) and Adrenal (RPKM 63.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (10224673..10297974, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (10219577..10292835, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10756871..10828811, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
Title: Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation.
Title: Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation.
These findings point to Cpx II being a likely key modulator of synaptic activity at the level of astrocytes.
Title: Identification of complexin II in astrocytes: a possible regulator of glutamate release in these cells.
Data showv that complexin 2 interacts with vesicle-associated membrane protein (VAMP) 2, syntaxins 3 and 4.
Title: Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.
results suggest that complexin II regulates degranulation by interacting with the SNARE complex containing syntaxin-3.
Title: Complexin II regulates degranulation in RBL-2H3 cells by interacting with SNARE complex containing syntaxin-3.
Transient increases in the levels of complexin I and complexin II proteins were detected in the injured cerebral cortex 6 h following TBI.
Title: Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
Complexin II regulates exocytosis positively by translocating to the plasma membrane and enhancing the Ca2+ sensitivity of fusion machinery.
Title: Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process.
complexins modulate neuroexocytosis after assembly of membrane-bridging SNARE complexes
Title: Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.
high levels of complexin seem to prevent SNARE complex recycling, presumably by displacing NSF and alpha-SNAP from SNARE complex.
Title: Overexpression of complexin in PC12 cells inhibits exocytosis by preventing SNARE complex recycling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE106621 (e-PCR)
- UniSTS:246339

CPLX2_9184 (e-PCR)
- UniSTS:468355

BF405787 (e-PCR)
- UniSTS:247963

D38613 (e-PCR)
- UniSTS:163536

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin-1 binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle docking involved in exocytosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: complexin-2

Names: CPX II; complexin II; synaphin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053878.3 → NP_446330.1 complexin-2

See identical proteins and their annotated locations for NP_446330.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

P84087

UniProtKB/TrEMBL

A6KB03

Conserved Domains (1) summary

pfam05835
Location:1 → 133

Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

10224673..10297974 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095303.2 → XP_038951231.1 complexin-2 isoform X1

UniProtKB/Swiss-Prot

P84087

UniProtKB/TrEMBL

A6KB03

Related

ENSRNOP00000072664.1

Conserved Domains (1) summary

pfam05835
Location:1 → 133

Synaphin; Synaphin protein
XM_017600440.3 → XP_017455929.1 complexin-2 isoform X1

UniProtKB/Swiss-Prot

P84087

UniProtKB/TrEMBL

A6KB03

Conserved Domains (1) summary

pfam05835
Location:1 → 133

Synaphin; Synaphin protein
XM_017600441.3 → XP_017455930.1 complexin-2 isoform X1

UniProtKB/Swiss-Prot

P84087

UniProtKB/TrEMBL

A6KB03

Conserved Domains (1) summary

pfam05835
Location:1 → 133

Synaphin; Synaphin protein
XM_063276028.1 → XP_063132098.1 complexin-2 isoform X1

UniProtKB/Swiss-Prot

P84087

UniProtKB/TrEMBL

A6KB03