Birc3 baculoviral IAP repeat-containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Birc3provided by MGI
Official Full Name: baculoviral IAP repeat-containing 3provided by MGI
Primary source: MGI:MGI:1197007
See related: Ensembl:ENSMUSG00000032000 AllianceGenome:MGI:1197007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.0) and 20 other tissues See more
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (7848698..7873199, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (7847468..7873205, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
Title: Birc3 and Tip1 are upregulated in renal ischemia reperfusion injury.
M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
Title: M1AP interacts with the mammalian ZZS complex and promotes male meiotic recombination.
Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.
Title: Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.
A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.
Title: A Novel Role of BIRC3 in Stemness Reprogramming of Glioblastoma.
Targeting cIAPs attenuates CCl4-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
Title: Targeting cIAPs attenuates CCl(4)-induced liver fibrosis by increasing MMP9 expression derived from neutrophils.
IAP inhibition or loss of both cIAP2 and XIAP resulted in a strong blockage in autophagic flux and mitophagy, suggesting that XIAP deficiency may also drive Crohn's Disease due to defects in autophagy.
Title: Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.
Shigella hijacks the glomulin-cIAP1-cIAP2-inflammasome axis to promote inflammation.
Title: Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.
These data reveal how, upon XIAP deficiency, a TLR-TNF-TNFR2 axis drives cIAP1-TRAF2 degradation to allow TLR or TNFR1 activation of RIPK3-caspase-8 and IL-1beta. This mechanism may explain why XIAP-deficient patients can exhibit symptoms reminiscent of patients with activating inflammasome mutations.
Title: XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.
These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase cIAP1.
Title: DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.
Drugs targeting XIAP and cIAP1/2 may be effective for osteosarcoma patients whose tumors express abundant RIPK1 and contain high levels of TNFalpha.
Title: IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:236051 (e-PCR)
- UniSTS:236051

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

AW107670 (e-PCR)
- UniSTS:179860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein polyubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 3

Names: IAP-1; RING-type E3 ubiquitin transferase BIRC3; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2; cellular inhibitor of apoptosis 2; inhibitor of apoptosis protein 1; mIAP-1

NP_031490.2

EC 2.3.2.27

XP_006509891.1

EC 2.3.2.27

XP_006509892.1

EC 2.3.2.27

XP_006509893.1

EC 2.3.2.27

XP_006509894.1

EC 2.3.2.27

XP_011240654.1

EC 2.3.2.27

XP_011240655.1

EC 2.3.2.27

XP_036010464.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007464.3 → NP_031490.2 baculoviral IAP repeat-containing protein 3

See identical proteins and their annotated locations for NP_031490.2

Status: VALIDATED

Source sequence(s)

AK162108, CA556605, U88908

Consensus CDS

CCDS22812.2

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Related

ENSMUSP00000013949.9, ENSMUST00000013949.15

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

7848698..7873199 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509829.5 → XP_006509892.1 baculoviral IAP repeat-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

E9QLX3, O08863

Conserved Domains (4) summary

smart00238
Location:311 → 381

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:497 → 585

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:433 → 482

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:606 → 659

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_006509828.5 → XP_006509891.1 baculoviral IAP repeat-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

E9QLX3, O08863

Conserved Domains (4) summary

smart00238
Location:333 → 403

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:519 → 607

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:455 → 504

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:628 → 681

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_006509831.5 → XP_006509894.1 baculoviral IAP repeat-containing protein 3 isoform X3

See identical proteins and their annotated locations for XP_006509894.1

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_011242353.4 → XP_011240655.1 baculoviral IAP repeat-containing protein 3 isoform X3

See identical proteins and their annotated locations for XP_011240655.1

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_036154571.1 → XP_036010464.1 baculoviral IAP repeat-containing protein 3 isoform X3

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_006509830.5 → XP_006509893.1 baculoviral IAP repeat-containing protein 3 isoform X3

See identical proteins and their annotated locations for XP_006509893.1

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
XM_011242352.4 → XP_011240654.1 baculoviral IAP repeat-containing protein 3 isoform X3

See identical proteins and their annotated locations for XP_011240654.1

UniProtKB/Swiss-Prot

E9QLX3, O08863

UniProtKB/TrEMBL

A2CGA5

Conserved Domains (4) summary

smart00238
Location:254 → 324

BIR; Baculoviral inhibition of apoptosis protein repeat

cd08329
Location:440 → 528

CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)

cd14394
Location:376 → 425

UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins

cd16713
Location:549 → 602

RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins