Dmbt1 deleted in malignant brain tumors 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmbt1provided by MGI
Official Full Name: deleted in malignant brain tumors 1provided by MGI
Primary source: MGI:MGI:106210
See related: Ensembl:ENSMUSG00000047517 AllianceGenome:MGI:106210
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRP; p80; Crpd; DBMT1; gp300; CRP-[a]; CRP-[b]
Summary: Enables zymogen binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within inner cell mass cell proliferation; positive regulation of epithelial cell differentiation; and response to bacterium. Located in extracellular matrix and zymogen granule membrane. Is extrinsic component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; retina; and spleen. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 494.9), large intestine adult (RPKM 367.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 73.2 cM

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (130633787..130723357)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (131032057..131121628)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model.
Title: DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model.
Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice.
Title: Deleted in malignant brain tumor 1 genetic variation confers urinary tract infection risk in children and mice.
No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis.
Title: No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis.
This study is to investigate the mechanism through which DMBT1 exerts its effects on allergic rhinitis progression.
Title: DMBT1 has a protective effect on allergic rhinitis.
We found that in 3 different populations, mucosal DMBT1 expression was significantly increased (2.5 fold) in individuals with dysplasia compared to multifocal atrophic gastritis without intestinal metaplasia; the increase was also observed in individuals with advanced gastritis and positive H. pylori infection.
Title: Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies.
a novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1
Title: A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins.
DMBT1 functions as an important endothelium-derived ECM protein that is able to bind angiogenic factors and promote adhesion, migration, proliferation, and angiogenesis as well as vascular repair.
Title: Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis.
Data show that deletion of hensin from intercalated cells results in the absence of typical alpha-intercalated cells and the consequent development of complete distal renal tubular acidosis (dRTA).
Title: Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis.
Carboxyl-terminal Asp(D) -3, Thr(T) -2, Lys(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 and PDZK1/CAP70.
Title: Interaction of carboxyl-terminal peptides of cytosolic-tail of apactin with PDZ domains of NHERF/EBP50 and PDZK-1/CAP70.
Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas
Title: Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparan sulfate binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info
enables zymogen binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blastocyst development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of columnar/cuboidal epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in induction of bacterial agglutination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: deleted in malignant brain tumors 1 protein

Names: apactin; crp-ductin; deleted in malignant brain tumors 1 pseudogene; ebnerin; glycoprotein 300; hensin; mucin-like glycoprotein; muclin; vomeroglandin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347632.2 → NP_001334561.1 deleted in malignant brain tumors 1 protein isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB005909, AC087063, AC110885, LXEJ02004976

Consensus CDS

CCDS85436.1

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

UniProtKB/TrEMBL

A0A140LI59

Related

ENSMUSP00000146685.3, ENSMUST00000208311.4
NM_007769.3 → NP_031795.2 deleted in malignant brain tumors 1 protein isoform 2 precursor

See identical proteins and their annotated locations for NP_031795.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB005909, AC087063, AC110885, LXEJ02004976

Consensus CDS

CCDS21909.1

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

UniProtKB/TrEMBL

E9QPG8

Related

ENSMUSP00000081556.5, ENSMUST00000084509.7

Conserved Domains (5) summary

smart00202
Location:324 → 424

SR; Scavenger receptor Cys-rich

smart00241
Location:1613 → 1860

ZP; Zona pellucida (ZP) domain

cd00041
Location:1494 → 1602

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam00100
Location:1731 → 1858

Zona_pellucida; Zona pellucida-like domain

pfam00530
Location:1376 → 1471

SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

130633787..130723357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507307.5 → XP_006507370.2 deleted in malignant brain tumors 1 protein isoform X9

Conserved Domains (2) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

cd00041
Location:999 → 1107

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507302.5 → XP_006507365.2 deleted in malignant brain tumors 1 protein isoform X5

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

smart00241
Location:1728 → 1975

ZP; Zona pellucida (ZP) domain

cd00041
Location:1609 → 1717

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507298.5 → XP_006507361.2 deleted in malignant brain tumors 1 protein isoform X1

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

smart00241
Location:1728 → 1975

ZP; Zona pellucida (ZP) domain

cd00041
Location:1609 → 1717

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507299.5 → XP_006507362.2 deleted in malignant brain tumors 1 protein isoform X2

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

smart00241
Location:1718 → 1965

ZP; Zona pellucida (ZP) domain

cd00041
Location:1599 → 1707

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507304.5 → XP_006507367.2 deleted in malignant brain tumors 1 protein isoform X6

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

smart00241
Location:1602 → 1849

ZP; Zona pellucida (ZP) domain

cd00041
Location:1483 → 1591

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507306.5 → XP_006507369.2 deleted in malignant brain tumors 1 protein isoform X8

UniProtKB/TrEMBL

A0A1D5RM72

Related

ENSMUSP00000148657.2, ENSMUST00000213064.3

Conserved Domains (3) summary

smart00202
Location:439 → 539

SR; Scavenger receptor Cys-rich

smart00241
Location:1589 → 1836

ZP; Zona pellucida (ZP) domain

cd00041
Location:1470 → 1578

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507305.5 → XP_006507368.2 deleted in malignant brain tumors 1 protein isoform X7

UniProtKB/TrEMBL

A0A1D5RM72

Conserved Domains (3) summary

smart00202
Location:718 → 818

SR; Scavenger receptor Cys-rich

smart00241
Location:1590 → 1837

ZP; Zona pellucida (ZP) domain

cd00041
Location:1471 → 1579

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507301.5 → XP_006507364.2 deleted in malignant brain tumors 1 protein isoform X4

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:428 → 528

SR; Scavenger receptor Cys-rich

smart00241
Location:1717 → 1964

ZP; Zona pellucida (ZP) domain

cd00041
Location:1598 → 1706

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
XM_006507300.5 → XP_006507363.2 deleted in malignant brain tumors 1 protein isoform X3

UniProtKB/Swiss-Prot

Q60997, Q80YC6, Q9JMJ9

Conserved Domains (3) summary

smart00202
Location:428 → 528

SR; Scavenger receptor Cys-rich

smart00241
Location:1717 → 1964

ZP; Zona pellucida (ZP) domain

cd00041
Location:1598 → 1706

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_019334.1: Suppressed sequence

Description

NG_019334.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.