Ltb lymphotoxin B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ltbprovided by MGI
Official Full Name: lymphotoxin Bprovided by MGI
Primary source: MGI:MGI:104796
See related: Ensembl:ENSMUSG00000024399 AllianceGenome:MGI:104796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p33; Tnfc; LTbeta; Tnfsf3; Tnlg1c
Summary: Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in positive regulation of interleukin-12 production. Acts upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human LTB (lymphotoxin beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 307.1), thymus adult (RPKM 119.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35413483..35415281)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35194507..35196305)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
Title: Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM(2.5).
The expression of lymphotoxin (LT)-B was significantly downregulated in the absence of T cells from nude mice and was recovered after the transfusion of T cells.
Title: T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B.
Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies.
Title: The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter.
Title: TNF-inducible expression of lymphotoxin-β in hepatic cells: an essential role for NF-κB and Ets1 transcription factors.
Lymphotoxin-beta-receptor (LTbetaR) signaling, a pathway essential for lymphoid organogenesis, abrogates tertiary lymphoid organ development in heart transplantation.
Title: Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses.
cigarette smoke induces pulmonary expression of lymphoid chemokines CXCL13 and CCL19 in a LTalphabeta-LTbetaR-dependent fashion
Title: Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis.
Sustained LT signaling represents a pathway involved in hepatitis-induced hepatocellular carcinoma.
Title: A lymphotoxin-driven pathway to hepatocellular carcinoma.
The adaptive immune system directly regulates liver regeneration via a T cell-derived lymphotoxin axis (LTalpha, LTbeta, LTbetaR).
Title: T cell-derived lymphotoxin regulates liver regeneration.
LTbetaR on hepatic stellate cells may be involved in signaling with LTbeta-expressing liver progenitor cells mediating recruitment of progenitor cells, hepatic stellate cells, & leukocytes for wound healing & regeneration during chronic liver injury.
Title: Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.
The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells.
Title: Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI662801 (e-PCR)
- UniSTS:180995

Ltb (e-PCR), detects polymorphism
- UniSTS:259369

NoName (e-PCR)
- UniSTS:484918

U12029 (e-PCR)
- UniSTS:160644

Ltb (e-PCR), detects polymorphism
- UniSTS:275858

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: lymphotoxin-beta

Names: LT-beta; TNF-C; tumor necrosis factor C; tumor necrosis factor ligand 1c; tumor necrosis factor ligand superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008518.2 → NP_032544.1 lymphotoxin-beta

See identical proteins and their annotated locations for NP_032544.1

Status: VALIDATED

Source sequence(s)

BC064062, CR974444, U16985

Consensus CDS

CCDS28690.1

UniProtKB/Swiss-Prot

P41155

UniProtKB/TrEMBL

A0A0U5JAA2, A4FUI4

Related

ENSMUSP00000025262.6, ENSMUST00000025262.6

Conserved Domains (1) summary

cd00184
Location:154 → 303

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...