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    Plekhg6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [ Mus musculus (house mouse) ]

    Gene ID: 213522, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Plekhg6provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 6provided by MGI
    Primary source
    MGI:MGI:2682298
    See related
    Ensembl:ENSMUSG00000038167 AllianceGenome:MGI:2682298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm155
    Summary
    Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be located in cell junction and centrosome. Is expressed in liver. Orthologous to human PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 20.7), small intestine adult (RPKM 19.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F3; 6 59.32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125339614..125358578, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125362651..125381615, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene sodium channel, nonvoltage-gated 1 alpha Neighboring gene lymphotoxin B receptor Neighboring gene STARR-seq mESC enhancer starr_17338 Neighboring gene tumor necrosis factor receptor superfamily, member 1a Neighboring gene predicted gene, 52918 Neighboring gene STARR-seq mESC enhancer starr_17342 Neighboring gene STARR-positive B cell enhancer ABC_E10410 Neighboring gene STARR-seq mESC enhancer starr_17349 Neighboring gene predicted gene, 32673 Neighboring gene STARR-seq mESC enhancer starr_17355 Neighboring gene STARR-positive B cell enhancer ABC_E8130 Neighboring gene CD9 antigen Neighboring gene predicted gene 28809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis. Wu D, et al. Cell Cycle, 2006 Jun. PMID 16721066, Free PMC Article
    2. GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. Wu D, et al. J Biol Chem, 2010 Sep 10. PMID 20634288, Free PMC Article
    3. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns, 2003 Jun. PMID 12799088
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC30363

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 6
    Names
    PH domain-containing family G member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198604.3 → NP_941006.2  pleckstrin homology domain-containing family G member 6

      See identical proteins and their annotated locations for NP_941006.2

      Status: VALIDATED

      Source sequence(s)
      AC140324
      Consensus CDS
      CCDS39642.1
      UniProtKB/Swiss-Prot
      E9QJZ0, Q8R0J1
      Related
      ENSMUSP00000037004.7, ENSMUST00000042647.7
      Conserved Domains (2) summary
      cd13244
      Location:408 → 505
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:165 → 351
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125339614..125358578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505867.3 → XP_006505930.1  pleckstrin homology domain-containing family G member 6 isoform X1

      See identical proteins and their annotated locations for XP_006505930.1

      UniProtKB/Swiss-Prot
      E9QJZ0, Q8R0J1
      Conserved Domains (2) summary
      cd13244
      Location:408 → 505
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:165 → 351
      RhoGEF; RhoGEF domain

    2. XM_017321495.2 → XP_017176984.1  pleckstrin homology domain-containing family G member 6 isoform X2

      Conserved Domains (2) summary
      smart00325
      Location:165 → 319
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:376 → 473
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0J1.2 GenPept UniProtKB/Swiss-Prot:Q8R0J1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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