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    Pank4 pantothenate kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 269614, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pank4provided by MGI
    Official Full Name
    pantothenate kinase 4provided by MGI
    Primary source
    MGI:MGI:2387466
    See related
    Ensembl:ENSMUSG00000029056 AllianceGenome:MGI:2387466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm42363; D030031I12Rik
    Summary
    Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Used to study cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.3), ovary adult (RPKM 20.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4; 4 E2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155048580..155065395)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154964123..154980940)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12242 Neighboring gene tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Neighboring gene STARR-positive B cell enhancer ABC_E9628 Neighboring gene STARR-positive B cell enhancer ABC_E8039 Neighboring gene STARR-positive B cell enhancer ABC_E6295 Neighboring gene STARR-positive B cell enhancer ABC_E2149 Neighboring gene STARR-positive B cell enhancer ABC_E8040 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene phospholipase C, eta 2 Neighboring gene STARR-positive B cell enhancer ABC_E10295 Neighboring gene peroxisomal biogenesis factor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Dibble CC, et al. Nature, 2022 Aug. PMID 35896750, Free PMC Article
    2. A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract. Sun M, et al. Hum Mutat, 2019 Apr. PMID 30585370
    3. Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine. Shibata K, et al. J Nutr, 1983 Oct. PMID 6619987
    4. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Zhou B, et al. Nat Genet, 2001 Aug. PMID 11479594
    5. Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. Sacksteder CA, et al. Biochemistry, 2006 Jul 4. PMID 16800626

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    4'-phosphopantetheine phosphatase
    Names
    inactive pantothenic acid kinase 4
    pantothenic acid kinase 4
    NP_001292733.1
    NP_001392980.1
    NP_001392981.1
    NP_001392982.1
    NP_001392983.1
    NP_001392984.1
    NP_001392985.1
    NP_766578.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305804.2 → NP_001292733.1  4'-phosphopantetheine phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001292733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX004788
      Consensus CDS
      CCDS84834.1
      UniProtKB/Swiss-Prot
      B1AZN5, B1AZN6, Q7M751, Q80YV4, Q8BQE9
      Related
      ENSMUSP00000064330.5, ENSMUST00000070953.11
      Conserved Domains (1) summary
      PLN02902
      Location:17 → 820
      PLN02902; pantothenate kinase

    2. NM_001406051.1 → NP_001392980.1  4'-phosphopantetheine phosphatase isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX004788

    3. NM_001406052.1 → NP_001392981.1  4'-phosphopantetheine phosphatase isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX004788

    4. NM_001406053.1 → NP_001392982.1  4'-phosphopantetheine phosphatase isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX004788

    5. NM_001406054.1 → NP_001392983.1  4'-phosphopantetheine phosphatase isoform 6

      Status: VALIDATED

      Source sequence(s)
      BX004788

    6. NM_001406055.1 → NP_001392984.1  4'-phosphopantetheine phosphatase isoform 7

      Status: VALIDATED

      Source sequence(s)
      BX004788

    7. NM_001406056.1 → NP_001392985.1  4'-phosphopantetheine phosphatase isoform 8

      Status: VALIDATED

      Source sequence(s)
      BX004788

    8. NM_172990.6 → NP_766578.2  4'-phosphopantetheine phosphatase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      BX004788
      Consensus CDS
      CCDS19019.1
      UniProtKB/Swiss-Prot
      Q80YV4
      Related
      ENSMUSP00000030931.5, ENSMUST00000030931.11
      Conserved Domains (1) summary
      PLN02902
      Location:17 → 773
      PLN02902; pantothenate kinase

    RNA

    1. NR_131230.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK039866, AK050894, BC050089, BX004788, W87071

    2. NR_176003.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX004788

    3. NR_176004.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX004788

    4. NR_176005.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX004788

    5. NR_176006.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX004788
      Related
      ENSMUST00000148934.8

    6. NR_176007.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX004788

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155048580..155065395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YV4.2 GenPept UniProtKB/Swiss-Prot:Q80YV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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