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    dah discontinuous actin hexagon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32459, updated on 10-May-2024

    Summary

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    Official Symbol
    dahprovided by FlyBase
    Official Full Name
    discontinuous actin hexagonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015926
    Locus tag
    Dmel_CG6157
    See related
    AllianceGenome:FB:FBgn0015926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Apd; CG6157; Dah; DAH; Dmel\CG6157; fs(1)dah
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in synaptic signaling. Predicted to be extrinsic component of membrane. Predicted to be active in plasma membrane. Orthologous to human DYTN (dystrotelin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    13B6-13B6; 1-50 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15328342..15331002)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15222375..15225035)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene germ cell-expressed bHLH-PAS Neighboring gene antisense RNA:CR44961 Neighboring gene mir-4957 stem loop Neighboring gene Topoisomerase 1 Neighboring gene antisense RNA:CR44998 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a Drosophila gene essential for early embryonic development and formation of cortical cleavage furrows. Zhang CX, et al. J Cell Biol, 1996 Aug. PMID 8769417, Free PMC Article
    2. Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11. Riggs B, et al. J Cell Biol, 2003 Oct 13. PMID 14530382, Free PMC Article
    3. The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo. Rothwell WF, et al. J Cell Sci, 1999 Sep. PMID 10444383
    4. A synthetic gene drive system for local, reversible modification and suppression of insect populations. Akbari OS, et al. Curr Biol, 2013 Apr 22. PMID 23541732, Free PMC Article
    5. Structure of the Drosophila DNA topoisomerase I gene and expression of messages with different lengths in the 3' untranslated region. Brown SD, et al. Gene, 1998 May 12. PMID 9602125

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellularization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extrinsic component of membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    discontinuous actin hexagon
    Names
    CG6157-PA
    CG6157-PB
    apodystrophin
    dah-PA
    dah-PB
    discontinuous actin hexagons

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15328342..15331002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078607.3 → NP_511162.1  discontinuous actin hexagon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7K8, Q24175
      Related
      FBpp0073824
      Conserved Domains (2) summary
      cd02345
      Location:281 → 329
      ZZ_dah; Zinc finger, ZZ type. Zinc finger present in Drosophila dah and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dah (discontinuous actin hexagon) is a membrane associated ...
      pfam09068
      Location:44 → 168
      EF-hand_2; EF hand

    2. NM_001272639.2 → NP_001259568.1  discontinuous actin hexagon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5I7K8, M9PHN1
      Conserved Domains (2) summary
      cd02345
      Location:278 → 326
      ZZ_dah; Zinc finger, ZZ type. Zinc finger present in Drosophila dah and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dah (discontinuous actin hexagon) is a membrane associated ...
      pfam09068
      Location:44 → 165
      EF-hand_2; EF hand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHN1 M9PHN1
    Q24175 Q24175
    Q8T9K5 Q8T9K5

    Gene LinkOut

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