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    Col4a1 Collagen type IV alpha 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33727, updated on 10-May-2024

    Summary

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    Official Symbol
    Col4a1provided by FlyBase
    Official Full Name
    Collagen type IV alpha 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000299
    Locus tag
    Dmel_CG4145
    See related
    AllianceGenome:FB:FBgn0000299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha(IV)1/Cg25C; alpha1; cg25c; cg25C; Cg25c; Cg25C; CG25C; CG4145; Cgc25; Cgc25C; Col IV alpha(1); col4a1; Col4A1; COL4A1; Col4alpha1; ColIValpha1; Coll; Coll IV; CT12803; Dcg; Dcg-1; dcg1; Dcg1; DCg1; Dmel\CG4145; gp125
    Summary
    An extracellular matrix structural constituent. Involved in several processes, including basement membrane organization; intestinal epithelial structure maintenance; and tube morphogenesis. Located in basement membrane. Is expressed in several structures, including circulatory system; embryonic/larval central nervous system; fat body; follicle cell; and plasmatocyte primordium. Used to study collagen disease and myopathy. Human ortholog(s) of this gene implicated in several diseases, including AMME complex; Alport syndrome (multiple); X-linked deafness 6; artery disease (multiple); and brain small vessel disease (multiple). Orthologous to several human genes including COL4A1 (collagen type IV alpha 1 chain) and COL4A6 (collagen type IV alpha 6 chain). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Col4a1 in Genome Data Viewer
    Location:
    25C1-25C1; 2-15 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5029609..5037279)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5029609..5037279)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Selenoprotein T Neighboring gene viking Neighboring gene uncharacterized protein Neighboring gene SP555 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 4-Hydroxy-2-nonenal Alkylated and Peroxynitrite Nitrated Proteins Localize to the Fused Mitochondria in Malpighian Epithelial Cells of Type IV Collagen Drosophila Mutants. Kiss AA, et al. Biomed Res Int, 2018. PMID 29651426, Free PMC Article
    2. Haemocytes accumulate collagen transcripts during Drosophila melanogaster metamorphosis. Knibiehler B, et al. Rouxs Arch Dev Biol, 1987 Apr. PMID 28305699
    3. Extracellular chloride signals collagen IV network assembly during basement membrane formation. Cummings CF, et al. J Cell Biol, 2016 May 23. PMID 27216258, Free PMC Article
    4. Reproduction and love: strategies of the organism's cellular defense system? De Loof A, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998 Aug. PMID 9827030
    5. Comparative analysis of the noncollagenous NC1 domain of type IV collagen: identification of structural features important for assembly, function, and pathogenesis. Netzer KO, et al. Protein Sci, 1998 Jun. PMID 9655338, Free PMC Article

    See all (215) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collagen IV of basement membranes: IV. Adaptive mechanism of collagen IV scaffold assembly in Drosophila.
      Title: Collagen IV of basement membranes: IV. Adaptive mechanism of collagen IV scaffold assembly in Drosophila.
    2. Results provide evidence that collagen IV produced in adipocytes is transported to the ovary to maintain proper germline stem cell (GSC) number in adult Drosophila females. Adipocyte-derived collagen IV acts through beta-integrin signaling to maintain normal levels of E-cadherin at the niche, thereby ensuring proper adhesion to GSCs.
      Title: Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females.
    3. The results demonstrated that col4a1 mutations affect the epithelia and, consequently, secretory function of the Malpighian tubules
      Title: 4-Hydroxy-2-nonenal Alkylated and Peroxynitrite Nitrated Proteins Localize to the Fused Mitochondria in Malpighian Epithelial Cells of Type IV Collagen Drosophila Mutants.
    4. Results of phenotypic features of Drosophila col4a1 mutants confirmed an essential role for type IV collagen in maintaining epithelial integrity, gut morphology and intestinal function and suggest that aberrant structure and function of the COL4A1 protein may also be a significant factor in modulating immunity.
      Title: Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction.
    5. Data show that laminin beta and collagen IV alpha1 were involved in cardiac and muscular abnormalities.
      Title: Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila.
    6. collagen IV functions to immobilize free Dpp in the Drosophila embryo
      Title: Multistep molecular mechanism for bone morphogenetic protein extracellular transport in the Drosophila embryo.
    7. Drosophila basement membrane collagen col4a1 mutations cause severe myopathy.
      Title: Drosophila basement membrane collagen col4a1 mutations cause severe myopathy.
    8. Data suggest that collagen IV acts to enhance ligand presentation to tubule cell receptors and is required to ensure ligand-mediated activation of the BMP pathway.
      Title: Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila.
    9. results identify a critical function of type IV collagens in modulating Dpp in the extracellular space during Drosophila development
      Title: Type IV collagens regulate BMP signalling in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oviduct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of collagen type IV trimer TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    collagen type IV alpha 1
    Names
    CG4145-PA
    CG4145-PB
    CG4145-PC
    Col4a1-PA
    Col4a1-PB
    Col4a1-PC
    collagen
    collagen IV
    collagen IV alpha1
    collagen IVa1
    collagen type IV
    collagenIV a1
    laminin alpha3,5
    preprocollagen alpha1(IV)
    procollagen IV
    type IV collagen
    type IV collagen, alpha-chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5029609..5037279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164616.2 → NP_723045.1  collagen type IV alpha 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723045.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V070, P08120, Q9VMV4
      UniProtKB/TrEMBL
      B7FNQ3
      Related
      FBpp0078641
      Conserved Domains (2) summary
      smart00111
      Location:1663 → 1777
      C4; C-terminal tandem repeated domain in type 4 procollagens
      pfam01391
      Location:765 → 824
      Collagen; Collagen triple helix repeat (20 copies)

    2. NM_164615.2 → NP_723044.1  collagen type IV alpha 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V070, P08120, Q9VMV4
      UniProtKB/TrEMBL
      B7FNQ3
      Related
      FBpp0078642
      Conserved Domains (2) summary
      smart00111
      Location:1663 → 1777
      C4; C-terminal tandem repeated domain in type 4 procollagens
      pfam01391
      Location:765 → 824
      Collagen; Collagen triple helix repeat (20 copies)

    3. NM_164617.2 → NP_723046.1  collagen type IV alpha 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V070, P08120, Q9VMV4
      UniProtKB/TrEMBL
      B7FNQ3
      Related
      FBpp0078640
      Conserved Domains (2) summary
      smart00111
      Location:1663 → 1777
      C4; C-terminal tandem repeated domain in type 4 procollagens
      pfam01391
      Location:765 → 824
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08120.3 P08120

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