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    Fkbp15 FK506 binding protein 15 [ Mus musculus (house mouse) ]

    Gene ID: 338355, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fkbp15provided by MGI
    Official Full Name
    FK506 binding protein 15provided by MGI
    Primary source
    MGI:MGI:2444782
    See related
    Ensembl:ENSMUSG00000066151 AllianceGenome:MGI:2444782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FKBO133; FKBP-15; FKBP133; FKBP-133; mKIAA0674; C430014M02Rik
    Summary
    Predicted to enable actin binding activity. Predicted to act upstream of or within endocytosis. Located in actin cytoskeleton; endosome; and growth cone. Is expressed in several structures, including central nervous system; lung; neural retina; peripheral nervous system ganglion; and thymus. Orthologous to human FKBP15 (FKBP prolyl isomerase family member 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 9.8), lung adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fkbp15 in Genome Data Viewer
    Location:
    4 B3; 4 33.08 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62218579..62278828, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62300342..62360596, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23148 Neighboring gene solute carrier family 31, member 2 Neighboring gene STARR-seq mESC enhancer starr_10422 Neighboring gene STARR-positive B cell enhancer ABC_E1277 Neighboring gene STARR-seq mESC enhancer starr_10423 Neighboring gene solute carrier family 31, member 1 Neighboring gene cell division cycle 26 Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. Nakajima O, et al. Biochem Biophys Res Commun, 2006 Jul 21. PMID 16756961
    2. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
    3. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
    4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0674, MGC169330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FK506-binding protein 15
    Names
    133 kDa FK506-binding protein
    133 kDa FKBP
    FK506-binding protein 133
    WAFL
    NP_001038993.1
    NP_001342314.1
    XP_006538097.1
    XP_030109487.1
    XP_036020098.1
    XP_036020099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045528.3 → NP_001038993.1  FK506-binding protein 15 isoform 1

      See identical proteins and their annotated locations for NP_001038993.1

      Status: VALIDATED

      Source sequence(s)
      AL683829, AL732548
      Consensus CDS
      CCDS51201.1
      UniProtKB/Swiss-Prot
      Q3TSY4, Q5SQG3, Q6P9Q6, Q80TU5
      Related
      ENSMUSP00000081575.4, ENSMUST00000084527.10
      Conserved Domains (4) summary
      pfam00254
      Location:192 → 285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam07321
      Location:677 → 806
      YscO; Type III secretion protein YscO
      cl23720
      Location:679 → 774
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23765
      Location:596 → 750
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001355385.2 → NP_001342314.1  FK506-binding protein 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683829, AL732548
      UniProtKB/TrEMBL
      B2RQ18
      Conserved Domains (4) summary
      pfam00254
      Location:192 → 285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      cl25732
      Location:556 → 915
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26464
      Location:934 → 1119
      Atrophin-1; Atrophin-1 family
      cl28087
      Location:378 → 489
      FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      62218579..62278828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164206.1 → XP_036020099.1  FK506-binding protein 15 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:505 → 690
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:122 → 430
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_030253627.1 → XP_030109487.1  FK506-binding protein 15 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:495 → 680
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:117 → 456
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006538034.4 → XP_006538097.1  FK506-binding protein 15 isoform X1

      UniProtKB/TrEMBL
      A0A6I8MWZ0
      Related
      ENSMUSP00000159322.2, ENSMUST00000239461.2
      Conserved Domains (4) summary
      PHA03247
      Location:944 → 1129
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:561 → 890
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:378 → 489
      PRK10263; DNA translocase FtsK; Provisional
      pfam00254
      Location:192 → 285
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    4. XM_036164205.1 → XP_036020098.1  FK506-binding protein 15 isoform X2

      UniProtKB/TrEMBL
      A0A6I8MWZ0
      Conserved Domains (3) summary
      PHA03247
      Location:792 → 977
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:409 → 738
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00254
      Location:40 → 133
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9Q6.2 GenPept UniProtKB/Swiss-Prot:Q6P9Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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