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    Egfr Epidermal growth factor receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37455, updated on 10-May-2024

    Summary

    Official Symbol
    Egfrprovided by FlyBase
    Official Full Name
    Epidermal growth factor receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003731
    Locus tag
    Dmel_CG10079
    See related
    AllianceGenome:FB:FBgn0003731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EC2-4; EFG-R; Egf; EGF; Egf-r; EGF-R; egfr; EgfR; EgFr; EGfr; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; Top; TOP; top/DER; top/flb; Torpedo; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr
    Summary
    Enables epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; oogenesis; and open tracheal system development. Is integral component of plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including ectoderm anlage; germ layer; gut section; head; and imaginal disc. Used to study alcohol use disorder and cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including amyotrophic lateral sclerosis type 19; breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and spinal disease (multiple). Orthologous to several human genes including ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Egfr in Genome Data Viewer
    Location:
    57E9-57F1; 2-95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21522420..21559977)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17409925..17447482)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44725 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tiwaz Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chorion-containing eggshell pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in compound eye cone cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of genital disc primordium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal closure, spreading of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye-antennal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in haltere development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leg disc proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lumen formation, open tracheal system IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in morphogenesis of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of compound eye retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in notum cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in notum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oenocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oocyte axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in photoreceptor cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in second mitotic wave involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing and notum subfield formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with cytoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    epidermal growth factor receptor
    Names
    CG10079-PA
    CG10079-PB
    DER-Ellipse
    EGF-receptor
    EGFR
    Egf receptor
    Egfr-PA
    Egfr-PB
    dEGFR
    drosophila epidermal growth factor receptor
    drosophila epidermal growth factor receptor homologue
    ellipse
    ellipse torpedo
    faint little ball
    morphological defects 1
    torpedo
    torpedo/DER
    NP_476758.1
    NP_476759.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21522420..21559977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057410.4 → NP_476758.1  epidermal growth factor receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6SAN1, Q8MLW0
      Related
      FBpp0071570
      Conserved Domains (7) summary
      smart00221
      Location:889 → 1145
      STYKc; Protein kinase; unclassified specificity
      smart00261
      Location:568 → 610
      FU; Furin-like repeats
      cd00064
      Location:253 → 296
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05057
      Location:881 → 1159
      PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
      pfam00757
      Location:204 → 352
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:370 → 498
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:523 → 635
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_057411.4 → NP_476759.1  epidermal growth factor receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18370, O61601, P04412, P81868, Q9W2G0
      Related
      FBpp0071571
      Conserved Domains (7) summary
      smart00221
      Location:938 → 1194
      STYKc; Protein kinase; unclassified specificity
      smart00261
      Location:617 → 659
      FU; Furin-like repeats
      cd00064
      Location:302 → 345
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05057
      Location:930 → 1208
      PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases
      pfam00757
      Location:253 → 401
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:419 → 547
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:572 → 684
      GF_recep_IV; Growth factor receptor domain IV