rt rotated abdomen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rtprovided by FlyBase
Official Full Name: rotated abdomenprovided by FlyBase
Primary source: FLYBASE:FBgn0003292
Locus tag: Dmel_CG6097
See related: AllianceGenome:FB:FBgn0003292
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6097; Dmel\CG6097; dPomt1; dPOMT1; DPOMT1; fs(3)neo1; pomt; POMT-1; POMT1; roa; Rot_abd; Rt
Summary: Contributes to dolichyl-phosphate-mannose-protein mannosyltransferase activity. Involved in several processes, including protein O-linked mannosylation; regulation of synaptic activity; and sarcomere organization. Located in endoplasmic reticulum. Part of dolichyl-phosphate-mannose-protein mannosyltransferase complex. Is expressed in several structures, including embryonic/larval gut; epithelium; and extended germ band embryo. Used to study Walker-Warburg syndrome and congenital muscular dystrophy-dystroglycanopathy type A1. Human ortholog(s) of this gene implicated in cardiomyopathy; cleft lip; lissencephaly; and muscular dystrophy (multiple). Orthologous to human POMT1 (protein O-mannosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 68C13-68C13; 3-36 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11584122..11587770, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11577222..11580870, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein tyrosine phosphatase 69D is a substrate of protein O-mannosyltransferases 1-2 that is required for the wiring of sensory axons in Drosophila.
Title: Protein tyrosine phosphatase 69D is a substrate of protein O-mannosyltransferases 1-2 that is required for the wiring of sensory axons in Drosophila.
POMTs were found to be required for proper axon connectivity of sensory neurons, suggesting that O-mannosylation regulates the sensory feedback controlling muscle contractions
Title: Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the Drosophila Embryo.
Study demonstrated that expression of RNA interference (RNAi) for the rt gene and the tw mutant was almost completely lethal and semi-lethal, respectively.
Title: Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome.
the model that dPOMT1-dependent glycosylation of Dg is necessary for proper synaptic function and raise the possibility that similar synaptic defects occur in the congenital muscular dystrophies.
Title: Synaptic defects in a Drosophila model of congenital muscular dystrophy.
establish a central role for Dystroglycan (Dg) in maintaining integrity in Drosophila larval muscles and demonstrate the importance of glycosylation to Dg function in Drosophila
Title: Dystroglycan and protein O-mannosyltransferases 1 and 2 are required to maintain integrity of Drosophila larval muscles.
Drosophila POMT1 and POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.
Title: The twisted abdomen phenotype of Drosophila POMT1 and POMT2 mutants coincides with their heterophilic protein O-mannosyltransferase activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to dolichyl-phosphate-mannose-protein mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, abdomen	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of dolichyl-phosphate-mannose-protein mannosyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rotated abdomen

Names: CG6097-PA; drosophila protein O-mannosyltransferase 1; rt-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11584122..11587770 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079301.4 → NP_524025.2 rotated abdomen [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524025.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q60GL9, Q8SYW7, Q94891, Q9VTK2

Related

FBpp0075877

Conserved Domains (4) summary

smart00472
Location:586 → 642

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

COG1928
Location:180 → 877

PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

pfam02366
Location:178 → 421

PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase

pfam16192
Location:672 → 875

PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase