U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CYP19A1 cytochrome P450 family 19 subfamily A member 1 [ Gallus gallus (chicken) ]

    Gene ID: 414854, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Symbol
    CYP19A1provided by CGNC
    Full Name
    cytochrome P450 family 19 subfamily A member 1provided by CGNC
    Primary source
    CGNC:10026
    See related
    Ensembl:ENSGALG00010022601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CYPXIX
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 10
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (9235646..9257340, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (9107722..9129427, complement)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene secretogranin III Neighboring gene adaptor related protein complex 4 epsilon 1 subunit Neighboring gene TNF alpha induced protein 8 like 3 Neighboring gene gliomedin Neighboring gene uncharacterized LOC107054185 Neighboring gene uncharacterized LOC107054183 Neighboring gene Dmx like 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcriptional regulation of CYP19A1 expression in chickens: ESR1, ESR2 and NR5A2 form a functional network. Guo Y, et al. Gen Comp Endocrinol, 2022 Jan 1. PMID 34710471
    2. CYP19A1 (aromatase) dominates female gonadal differentiation in chicken (Gallus gallus) embryos sexual differentiation. Jin K, et al. Biosci Rep, 2020 Oct 30. PMID 32990306, Free PMC Article
    3. The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen. McPhaul MJ, et al. J Biol Chem, 1988 Nov 5. PMID 3182796
    4. Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Campine aromatase genes. Matsumine H, et al. J Biol Chem, 1991 Oct 25. PMID 1939054
    5. Transcription of CYP19A1 is directly regulated by SF-1 in the theca cells of ovary follicles in chicken. Wang J, et al. Gen Comp Endocrinol, 2017 Jun 1. PMID 28347743

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional regulation of CYP19A1 expression in chickens: ESR1, ESR2 and NR5A2 form a functional network.
      Title: Transcriptional regulation of CYP19A1 expression in chickens: ESR1, ESR2 and NR5A2 form a functional network.
    2. CYP19A1 (aromatase) dominates female gonadal differentiation in chicken (Gallus gallus) embryos sexual differentiation.
      Title: CYP19A1 (aromatase) dominates female gonadal differentiation in chicken (Gallus gallus) embryos sexual differentiation.
    3. ESR2 is a potential regulator of CYP19A1 expression in the theca cells of chicken follicles.
      Title: A transcriptomic comparison of theca and granulosa cells in chicken and cattle follicles reveals ESR2 as a potential regulator of CYP19A1 expression in the theca cells of chicken follicles.
    4. SF-1 activates CYP19A1 mRNA expression via a conserved binding site in chicken ovary
      Title: Transcription of CYP19A1 is directly regulated by SF-1 in the theca cells of ovary follicles in chicken.
    5. TCDD inhibits steroidogenesis by influencing STAR, HSD3B and CYP19A1 mRNA expression.
      Title: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on secretion of steroids and STAR, HSD3B and CYP19A1 mRNA expression in chicken ovarian follicles.
    6. FoxL2 is an early regulator of ovarian development in birds and may be involved in aromatase transcription regulation
      Title: Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development.
    7. transcription factor FOXL2 lies upstream of aromatase in avian sex determination
      Title: Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    aromatase
    Names
    aromatase CYP19A1
    cytochrome P-450AROM
    cytochrome P450 19A1
    cytochrome P450, family 19, subfamily A, polypeptide 1
    estrogen synthase
    estrogen synthetase
    NP_001001761.3
    NP_001351628.2
    XP_046754903.1
    XP_046780576.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001761.4 → NP_001001761.3  aromatase

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000245
      UniProtKB/TrEMBL
      A0A8V0ZQZ6

    2. NM_001364699.2 → NP_001351628.2  aromatase

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000245
      UniProtKB/TrEMBL
      A0A8V0ZQZ6

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      9235646..9257340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046898947.1 → XP_046754903.1  aromatase isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZQZ6
      Related
      ENSGALP00010033260.1, ENSGALT00010055011.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      9107722..9129427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046924620.1 → XP_046780576.1  aromatase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19098.1 GenPept UniProtKB/Swiss-Prot:P19098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.