Fzd2 frizzled class receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fzd2provided by RGD
Official Full Name: frizzled class receptor 2provided by RGD
Primary source: RGD:71012
See related: Ensembl:ENSRNOG00000021962 AllianceGenome:RGD:71012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fz-10; Fzd10
Summary: Enables Wnt-activated receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (88061988..88063898)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87561866..87563776)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90550147..90552057)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel pathogenesis of the contribution of downregulation of neurotrophins to the inhibition of the interaction between Wnt5a and Frizzled-2 in astrocytes in minimal hepatic encephalopathy
Title: The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy.
H9c2 cell treatment with resveratrol significantly reduces the expression of Frizzled2 and Wnt5a.
Title: Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells.
These findings demonstrated that the Wnt5a/Fzd2 signaling pathway contributed to increasing intracellular Ca(2) in nerve cells under physiological and pathological conditions
Title: Suppression of Frizzled-2-mediated Wnt/Ca²⁺ signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury.
upon binding to Wnt5a, increased Frizzled-2 expression after hypoxia/reoxygenation treatment activated intracellular calcium release in H9c2 cells
Title: Suppression of rat Frizzled-2 attenuates hypoxia/reoxygenation-induced Ca2+ accumulation in rat H9c2 cells.
role of phosphodiesterase and of cGMP in Frizzled-2 signaling
Title: Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.
Highly upregulated expression of Wnt5a and its receptor frizzled 2 implicates this pathway in differentiation of quiescent hepatic stellate cells into myofibroblasts.
Title: Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC16008P1 (e-PCR)
- UniSTS:271446

Fzd2 (e-PCR), detects polymorphism
- UniSTS:508385

Fzd2 (e-PCR), detects polymorphism
- UniSTS:508386

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, calcium modulating pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hard palate development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hard palate development	ISO Inferred from Sequence Orthology more info
involved_in inner ear receptor cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in membranous septum morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membranous septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in muscular septum morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: frizzled-2

Names: Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled family receptor 2; fz-2; rFz2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172035.2 → NP_742032.2 frizzled-2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q08464

UniProtKB/TrEMBL

A6HJL6, G3V954

Related

ENSRNOP00000036154.2, ENSRNOT00000032944.3

Conserved Domains (2) summary

cd07464
Location:40 → 166

CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor

cd15245
Location:239 → 568

7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors