Acot10 acyl-CoA thioesterase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot10provided by MGI
Official Full Name: acyl-CoA thioesterase 10provided by MGI
Primary source: MGI:MGI:1928940
See related: Ensembl:ENSMUSG00000047565 AllianceGenome:MGI:1928940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p48; Acate3; MT-ACT48
Summary: Enables acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Located in mitochondrion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 15 A2; 15 8.23 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (20665300..20666836, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (20665214..20666750, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acyl-CoA metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 10, mitochondrial

Names: acyl-Coenzyme A thioesterase 3, mitochondrial; mitochondrial 48 kDa acyl-CoA thioester hydrolase 2; mt-ACT48.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022816.2 → NP_073727.2 acyl-coenzyme A thioesterase 10, mitochondrial precursor

See identical proteins and their annotated locations for NP_073727.2

Status: PROVISIONAL

Source sequence(s)

AJ238894, BC108959

Consensus CDS

CCDS27395.1

UniProtKB/Swiss-Prot

A0FJF7, Q32MW2, Q32MW3

Related

ENSMUSP00000051333.5, ENSMUST00000052910.6

Conserved Domains (1) summary

cd03442
Location:286 → 406

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...