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    Ranbp10 RAN binding protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 74334, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ranbp10provided by MGI
    Official Full Name
    RAN binding protein 10provided by MGI
    Primary source
    MGI:MGI:1921584
    See related
    Ensembl:ENSMUSG00000037415 AllianceGenome:MGI:1921584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432417N03Rik
    Summary
    Enables beta-tubulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Acts upstream of or within microtubule cytoskeleton organization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and nervous system. Orthologous to human RANBP10 (RAN binding protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 43.4), liver E14 (RPKM 37.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106494940..106560463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105768308..105833831, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene enkurin domain containing 1 Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8850 Neighboring gene STARR-positive B cell enhancer ABC_E2272 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Kunert S, et al. Blood, 2009 Dec 24. PMID 19801445
    2. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Meyer I, et al. Blood, 2012 Oct 25. PMID 22936655
    3. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Wang D, et al. Biochem Biophys Res Commun, 2004 Jan 9. PMID 14684163
    4. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. Wang D, et al. J Biol Chem, 2002 Sep 27. PMID 12147692
    5. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RanBP10 inhibits premature microtubule polymerization of beta1-tubulin and plays a pivotal role in thrombus stabilization.
      Title: Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.
    2. Data suggest that RanBP10 plays an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.
      Title: The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ran-binding protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145824.5 → NP_665823.3  ran-binding protein 10

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Consensus CDS
      CCDS22613.1
      UniProtKB/Swiss-Prot
      Q69ZJ1, Q6VN19, Q8C328, Q8R1E6
      UniProtKB/TrEMBL
      A0A0R4J0G4, A9UGK3
      Related
      ENSMUSP00000159340.2, ENSMUST00000239468.2
      Conserved Domains (4) summary
      smart00667
      Location:257 → 284
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:291 → 347
      CTLH; C-terminal to LisH motif
      smart00757
      Location:507 → 604
      CRA; CT11-RanBPM
      cd12909
      Location:77 → 219
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106494940..106560463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243813.1 → XP_030099673.1  ran-binding protein 10 isoform X1

      Conserved Domains (4) summary
      smart00667
      Location:150 → 177
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:400 → 497
      CRA; CT11-RanBPM
      cd12909
      Location:10 → 112
      SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
      pfam10607
      Location:184 → 238
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    2. XM_030243815.1 → XP_030099675.1  ran-binding protein 10 isoform X3

      Conserved Domains (3) summary
      smart00667
      Location:28 → 55
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:62 → 118
      CTLH; C-terminal to LisH motif
      smart00757
      Location:278 → 375
      CRA; CT11-RanBPM

    3. XM_030243814.1 → XP_030099674.1  ran-binding protein 10 isoform X2

      Conserved Domains (4) summary
      smart00667
      Location:125 → 152
      LisH; Lissencephaly type-1-like homology motif
      smart00757
      Location:375 → 472
      CRA; CT11-RanBPM
      pfam10607
      Location:159 → 213
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cl02614
      Location:2 → 87
      SPRY; SPRY domain

    4. XM_006531426.1 → XP_006531489.1  ran-binding protein 10 isoform X3

      See identical proteins and their annotated locations for XP_006531489.1

      Conserved Domains (3) summary
      smart00667
      Location:28 → 55
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:62 → 118
      CTLH; C-terminal to LisH motif
      smart00757
      Location:278 → 375
      CRA; CT11-RanBPM

    5. XM_011248526.1 → XP_011246828.1  ran-binding protein 10 isoform X3

      See identical proteins and their annotated locations for XP_011246828.1

      Conserved Domains (3) summary
      smart00667
      Location:28 → 55
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:62 → 118
      CTLH; C-terminal to LisH motif
      smart00757
      Location:278 → 375
      CRA; CT11-RanBPM

    6. XM_006531428.5 → XP_006531491.1  ran-binding protein 10 isoform X4

      Conserved Domains (3) summary
      smart00668
      Location:32 → 88
      CTLH; C-terminal to LisH motif
      smart00757
      Location:248 → 345
      CRA; CT11-RanBPM
      cl26729
      Location:1 → 20
      LisH
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VN19.2 GenPept UniProtKB/Swiss-Prot:Q6VN19

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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