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    CKS Nucleotide-diphospho-sugar transferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841733, updated on 7-Sep-2023

    Summary

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    Gene symbol
    CKS
    Gene description
    Nucleotide-diphospho-sugar transferases superfamily protein
    Primary source
    Araport:AT1G53000
    Locus tag
    AT1G53000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCKS; CMP-KDO synthetase; KDSB
    Summary
    Encodes a mitochondrial-localized CMP-KDO (3-deoxy-D-manno-octulosonate) synthetase. This is the enzyme activating KDO as a nucleotide sugar prior to its incorporation into rhamnogalacturonan-II. Heterozygous mutants are defective in pollen development and in pollen tube elongation.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (19744948..19747804, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene GTP-binding family protein Neighboring gene thioredoxin family protein Neighboring gene RING/U-box superfamily protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Arabidopsis CTP:3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO synthetase), the enzyme that activates KDO during rhamnogalacturonan II biosynthesis. Kobayashi M, et al. Plant Cell Physiol, 2011 Oct. PMID 21893514
    2. Cloning and characterization of cytidine monophosphate-3-deoxy-d-manno-octulosonate synthetase from Arabidopsis thaliana. Misaki R, et al. J Biosci Bioeng, 2009 Dec. PMID 19914588
    3. Multiple lines of evidence localize signaling, morphology, and lipid biosynthesis machinery to the mitochondrial outer membrane of Arabidopsis. Duncan O, et al. Plant Physiol, 2011 Nov. PMID 21896887, Free PMC Article
    4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis CTP:KDO cytidylyltransferase (CMP-KDO synthetase; CKS), the enzyme activating 3-Deoxy-D-manno-2-octulosonic acid as a nucleotide sugar prior to its incorporation into rhamnogalacturonan II.[CKS]
      Title: Characterization of Arabidopsis CTP:3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO synthetase), the enzyme that activates KDO during rhamnogalacturonan II biosynthesis.
    2. Cytidine monophosphate-3-deoxy-d-manno-octulosonate synthetase showed a ubiquitous expression, the activity at an optimal pH of 8.0, and a requirement of Mg2+. CMPKDO-S catalyzes the production of sugar nucleotide CMP-KDOs. [CMPKDO-S]
      Title: Cloning and characterization of cytidine monophosphate-3-deoxy-d-manno-octulosonate synthetase from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001333568.1
    NM_104178.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-manno-octulosonate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Nucleotide-diphospho-sugar transferases superfamily protein
    NP_175708.2
    • KDSB; FUNCTIONS IN: 3-deoxy-manno-octulosonate cytidylyltransferase activity, nucleotidyltransferase activity; INVOLVED IN: lipopolysaccharide biosynthetic process; LOCATED IN: mitochondrion; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 3-deoxy-D-manno-octulosonate cytidylyltransferase (InterPro:IPR004528), Acylneuraminate cytidylyltransferase (InterPro:IPR003329); Has 7496 Blast hits to 7495 proteins in 1549 species: Archae - 38; Bacteria - 4007; Metazoa - 8; Fungi - 0; Plants - 48; Viruses - 0; Other Eukaryotes - 3395 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19744948..19747804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104178.5 → NP_175708.2  Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175708.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C920
      UniProtKB/TrEMBL
      A0A178W2K9, A0A5S9WPH5
      Conserved Domains (1) summary
      PLN02917
      Location:1 → 290
      PLN02917; CMP-KDO synthetase

    2. NM_001333568.1 → NP_001322925.1  Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W2K9, A0A1P8AVI3, A0A5S9WPH5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C920.1

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