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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.


Current Build 155

Released April 9, 2021

Homo sapiens
chr10:6279949 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Variation Type
SNV Single Nucleotide Variation
T=0.345310 (91400/264690, TOPMED)
T=0.336404 (47067/139912, GnomAD)
A=0.32667 (5475/16760, 8.3KJPN) (+ 5 more)
T=0.38312 (5930/15478, ALFA)
A=0.025 (10/402, SGDP_PRJ)
T=0.282 (61/216, Qatari)
A=0.014 (2/145, Vietnamese)
A=0.00 (0/16, Siberian)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
0 citations
Genomic View
See rs on genome

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 10 NC_000010.11:g.6279949A>T
GRCh37.p13 chr 10 NC_000010.10:g.6321912A>T

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 15478 A=0.61688 T=0.38312
European Sub 11114 A=0.61229 T=0.38771
African Sub 2898 A=0.6667 T=0.3333
African Others Sub 114 A=0.570 T=0.430
African American Sub 2784 A=0.6706 T=0.3294
Asian Sub 112 A=0.250 T=0.750
East Asian Sub 86 A=0.22 T=0.78
Other Asian Sub 26 A=0.35 T=0.65
Latin American 1 Sub 146 A=0.582 T=0.418
Latin American 2 Sub 610 A=0.544 T=0.456
South Asian Sub 98 A=0.48 T=0.52
Other Sub 500 A=0.638 T=0.362


Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 A=0.654690 T=0.345310
gnomAD - Genomes Global Study-wide 139912 A=0.663596 T=0.336404
gnomAD - Genomes European Sub 75796 A=0.69260 T=0.30740
gnomAD - Genomes African Sub 41880 A=0.66335 T=0.33665
gnomAD - Genomes American Sub 13634 A=0.56667 T=0.43333
gnomAD - Genomes Ashkenazi Jewish Sub 3324 A=0.7464 T=0.2536
gnomAD - Genomes East Asian Sub 3130 A=0.3045 T=0.6955
gnomAD - Genomes Other Sub 2148 A=0.6555 T=0.3445
8.3KJPN JAPANESE Study-wide 16760 A=0.32667 T=0.67333
SGDP_PRJ Global Study-wide 402 A=0.025 T=0.975
Qatari Global Study-wide 216 A=0.718 T=0.282
A Vietnamese Genetic Variation Database Global Study-wide 145 A=0.014 T=0.986
Siberian Global Study-wide 16 A=0.00 T=1.00

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement A= T
GRCh38.p13 chr 10 NC_000010.11:g.6279949= NC_000010.11:g.6279949A>T
GRCh37.p13 chr 10 NC_000010.10:g.6321912= NC_000010.10:g.6321912A>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

29 SubSNP, 8 Frequency submissions
No Submitter Submission ID Date (Build)
1 SC_SNP ss16093968 Feb 27, 2004 (120)
2 SC_SNP ss18420117 Feb 27, 2004 (120)
3 SC_SNP ss18628676 Feb 27, 2004 (120)
4 1000GENOMES ss109197529 Jan 23, 2009 (130)
5 1000GENOMES ss115305489 Jan 25, 2009 (130)
6 GMI ss154522875 Dec 01, 2009 (131)
7 COMPLETE_GENOMICS ss168979056 Jul 04, 2010 (132)
8 BCM-HGSC-SUB ss207073460 Jul 04, 2010 (132)
9 BL ss254025896 May 09, 2011 (134)
10 GMI ss280464796 May 04, 2012 (137)
11 PJP ss290900185 May 09, 2011 (134)
12 TISHKOFF ss561745467 Apr 25, 2013 (138)
13 1000GENOMES ss1336130449 Aug 21, 2014 (142)
14 HAMMER_LAB ss1806238352 Sep 08, 2015 (146)
15 WEILL_CORNELL_DGM ss1930478332 Feb 12, 2016 (147)
16 USC_VALOUEV ss2154204337 Dec 20, 2016 (150)
17 HUMAN_LONGEVITY ss2172359169 Dec 20, 2016 (150)
18 TOPMED ss2335068238 Dec 20, 2016 (150)
19 SYSTEMSBIOZJU ss2627450064 Nov 08, 2017 (151)
20 GRF ss2698428262 Nov 08, 2017 (151)
21 TOPMED ss3110665989 Nov 08, 2017 (151)
22 BIOINF_KMB_FNS_UNIBA ss3645115694 Oct 12, 2018 (152)
23 PACBIO ss3791764124 Jul 13, 2019 (153)
24 PACBIO ss3796645904 Jul 13, 2019 (153)
25 KHV_HUMAN_GENOMES ss3813062748 Jul 13, 2019 (153)
26 SGDP_PRJ ss3873453655 Apr 26, 2020 (154)
27 GNOMAD ss4212319814 Apr 26, 2021 (155)
28 TOPMED ss4841245543 Apr 26, 2021 (155)
29 TOMMO_GENOMICS ss5196097218 Apr 26, 2021 (155)
30 gnomAD - Genomes NC_000010.11 - 6279949 Apr 26, 2021 (155)
31 Qatari NC_000010.10 - 6321912 Apr 26, 2020 (154)
32 SGDP_PRJ NC_000010.10 - 6321912 Apr 26, 2020 (154)
33 Siberian NC_000010.10 - 6321912 Apr 26, 2020 (154)
34 8.3KJPN NC_000010.10 - 6321912 Apr 26, 2021 (155)
35 TopMed NC_000010.11 - 6279949 Apr 26, 2021 (155)
36 A Vietnamese Genetic Variation Database NC_000010.10 - 6321912 Jul 13, 2019 (153)
37 ALFA NC_000010.11 - 6279949 Apr 26, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss109197529, ss115305489, ss168979056, ss207073460, ss254025896, ss280464796, ss290900185 NC_000010.9:6361917:A:T NC_000010.11:6279948:A:T (self)
12520262, 25470635, 6720691, 54066525, 5978629, ss561745467, ss1336130449, ss1806238352, ss1930478332, ss2154204337, ss2335068238, ss2627450064, ss2698428262, ss3791764124, ss3796645904, ss3873453655, ss5196097218 NC_000010.10:6321911:A:T NC_000010.11:6279948:A:T (self)
342417987, 35685414, 56791198, 12066249841, ss2172359169, ss3110665989, ss3645115694, ss3813062748, ss4212319814, ss4841245543 NC_000010.11:6279948:A:T NC_000010.11:6279948:A:T (self)
ss154522875 NT_008705.16:6261911:A:T NC_000010.11:6279948:A:T (self)
ss16093968, ss18420117, ss18628676 NT_077569.2:684807:A:T NC_000010.11:6279948:A:T (self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

No publications for rs10906151


The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post596+ae089ad